Molecular mechanisms of left-right asymmetric morphogenesis in visceral organs and limb
Project/Area Number |
22770215
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Single-year Grants |
Research Field |
Developmental biology
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Research Institution | Osaka University |
Principal Investigator |
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Project Period (FY) |
2010 – 2012
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Project Status |
Completed (Fiscal Year 2012)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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Keywords | 発生・分化 / 左右軸 / 器官形成 / Pitx2 / Fgf10 |
Research Abstract |
About left-right asymmetric morphogenesis in visceral organs and limb, I discovered the following molecular mechanisms: (1)Endocardium, which receives Fgf signals, has important role in morphogenesis of heart outflow tract. (2)Morphogenesis of heart outflow tract involves several Fgf factors in addition to Fgf10. (3)Expression of Pitx2is initiated in left lateral plate mesoderm, and also begins at paraxial mesoderm cells in the limb bud. (4)Cell proliferation rate of Pitx2-expressing cells in dorso-ventral region of left limb is different between wild type and Pitx2mutant embryos. Pitx2 inhibits cell proliferation in these cells.
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Report
(4 results)
Research Products
(16 results)
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[Journal Article] Cilia at the Node of Mouse Embryos Sense Fluid Flow for Left-Right Determination via Pkd22012
Author(s)
Yoshiba S, Shiratori H, Kuo IY, Kawasumi A, Shinohara K, Nonaka S, Asai Y, Sasaki G, Belo JA, Sasaki H, Nakai J, Dworniczak B, Ehrlich BE, Pennekamp P, Hamada H
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Journal Title
Science
Volume: 338(6104):226-3
Issue: 6104
Pages: 226-231
DOI
Related Report
Peer Reviewed
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[Journal Article] Dysregulation of the PDGFRA gene causes inflow tract anomalies including TAPVR: integrating evidence from human genetics and model organisms2010
Author(s)
Bleyl SB, Saijoh Y, Bax NA, Gittenberger-de Groot AC, Wisse LJ, Chapman SC, Hunter J, Shiratori H, Hamada H, Yamada S, Shiota K, Klewer SE, Leppert MF, Schoenwolf GC
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Journal Title
Human Molecular Genetics
Volume: 19(7)
Issue: 1
Pages: 1286-1301
DOI
Related Report
Peer Reviewed
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