| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
|
|---|
| Research Abstract |
About left-right asymmetric morphogenesis in visceral organs and limb, I discovered the following molecular mechanisms:
（1）Endocardium, which receives Fgf signals, has important role in morphogenesis of heart outflow tract.
（2）Morphogenesis of heart outflow tract involves several Fgf factors in addition to Fgf10.
（3）Expression of Pitx2is initiated in left lateral plate mesoderm, and also begins at paraxial mesoderm cells in the limb bud.
(4)Cell proliferation rate of Pitx2-expressing cells in dorso-ventral region of left limb is different between wild type and Pitx2mutant embryos. Pitx2 inhibits cell proliferation in these cells.
|
