| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2010: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Research Abstract |
To identify the evolutionary process of somatotopic organization in vertebrate trigeminal system, we compared trigeminal nerve organization in developing turtle, chick, and mouse. We found that, while mandibular and maxillary branch somatotopy is conserved in turtle, these branches in the chick are not strictly spatially segregated, and their position in the trigeminal tract is inversed, as compared to mouse. Furthermore, by using this specific marker in combination with Hoxa2 and axonal tracings from the periphery, we mapped the position of chick PrV in rhombomere(r) 1, unlike mouse PrV that mainly maps in r2-r3. Thus, somatotopy of trigeminal ganglion and nerve organization is only partially conserved through amniote evolution, possibly in relation to the modification of facial somatosensory structures and morphologies.
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