Studies on the molecular mechanisms of left-right polarization of epithelial cells during left-right asymmetric development of Drosophila gut
| Project/Area Number |
22770221
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Tokyo University of Science |
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Principal Investigator |
MAEDA Reo 東京理科大学, 基礎工学部・生物工学科, 助教 (40453831)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 左右非対称性 / ショウジョウバエ / 消化管 / 上皮細胞 / Myosin31DF / DE-Cadherin中心体 / 極性 / 発生生物学 / 左右極性 / 中心体 / 発生 |
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| Research Abstract |
Many bilateral animals show left-right(LR) asymmetry in their body. Many genes involved in the left-right axis formation have been identified in vertebrates. However, the cellular mechanisms how LR asymmetric organ morphology is generated are still largely unknown. In this study, we studied the LR asymmetry of Drosophila gut. Our results suggest that Myo31DF and DE-Cad are required for the LR biased cell shape formation and LR biased cell shape is sufficient to induce the directional LR asymmetric morphogenesis of the Drosophila gut.
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Report
(3 results)
Research Products
(27 results)
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[Journal Article] Canonical Wnt signaling in the visceral muscle is required for left. right asymmetric development of the Drosophila midgut2012
Author(s)
Junpei Kuroda, Mitsutoshi Nakamura, Masashi Yoshida, Haruka Yamamoto, Takaaki Maeda, Kiichiro Taniguchi, Naotaka Nakazawa, Ryo Hatori, Akira Ishio, Ayumi Ozaki, Shunsuke Shimaokaa, Tamiko Ito, Hironao Iida, Takashi Okumura, Reo Maeda, Kenji Matsuno
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Journal Title
Mechanisms of Development
Volume: vol.128
Pages: 625-639
Related Report
Peer Reviewed
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