| Project/Area Number |
22770222
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | Suzuka National College of Technology |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 赤血球 / 両生類 / 変態 / 甲状腺ホルモン / エリスロポエチン / アフリカツメガエル / 細胞増殖 / 細胞・組織 / 動物 / 発生・分化 |
|---|
| Research Abstract |
During amphibian metamorphosis, most of the organs and tissues are remodeled. The red blood cells are also remodeled from larval type to adult type, but the mechanism regulating this switch is largely unknown. In this study, I suggest that not thyroid hormone, but erythropoietin induces the red blood cell transition in Xenopus laevis. I also found that the red blood cell transition in Xenopus does not synchronize to metamorphosis, showing striking contrast to the case in other terrestrial anuran species. This would suggest that the mechanism governs the transition in Xenopus is distinct from those in other species.
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