| Project/Area Number |
22770229
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
TAKEUCHI Masaki 独立行政法人理化学研究所, ボディプラン研究グループ, 専門職研究員 (00392019)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 体軸 / オーガナイザー / 三胚葉 / 条鰭類 / 両生類 / siamois / Wntシグナル / nodal / 初期発生 / ポリプテルス / 脊椎動物 / ホメオボックス転写因子 |
|---|
| Research Abstract |
Xenopus siamois is a homeobox gene cording for a transcriptional mediator of the dorsal Wnt signaling pathway and is necessary for the head formation. Despite its importance in Xenopus development, no siamois-related genes have been found in other taxa. In this study, I found a novel siamois-related gene, dioskouroi, in bichir. The bichir gene, which is different from siamois, plays roles in not only organizer formation but also endoderm differentiation endogenously. These results lead to a hypothesis that the siamois-related protogene in a common ancestor of bony fishes played central role in early embryogenesis.
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