Molecular evolution of ancient TIR containing gene family in innate immunity
| Project/Area Number |
22770232
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Evolutionary biology
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| Research Institution | Saitama University |
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Principal Investigator |
HIBINO Taku 埼玉大学, 教育学部, 准教授 (60513835)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | Toll-like receptor / ウニ / ウミユリ / 棘皮動物 / 自然免疫 / トリノアシ / 分子進化 |
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| Research Abstract |
To unveil a repertoire of Toll-like receptors (TLRs) and TIR containing signaling molecules in a basal deuterostome, we analyzed EST of a stalked crinoid, Metacrinus rotundas, whose embryonic and larval cDNA have been sequenced by Next Gene Sequencing. So far, we identified 6 TLRs that consist of 3 genes of fly-type and 3 genes of vertebrate type TLRs. MyD88-like genes and Sarm-like genes were also identified in the cDNA of the sea lily, suggesting these genes exist in a basal deuterostome. We found unique TIR containing gene families, CARD-TIR and TPR-TIR, in the sequencing data of the sea lily, which have not been in the genome of the sea urchin, but in that of amphioxus. These data suggest a basal deuterostome could utilize multigenes of TLRs and various types of TIR containing genes. And the refinement of TLRs and signaling molecules could happen after the appearance of acquired immunity.
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Report
(3 results)
Research Products
(10 results)
