Comparative transcriptome and methylome study in humans and chimpanzees

• Project/Area Number: 22770240
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Physical anthropology
• Research Institution: Kyoto University
• Principal Investigator: GO Yasuhiro 京都大学, 霊長類研究所, 助教 (50377123)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 進化 / 霊長類 / ゲノム / 遺伝子発現 / チンパンジー / トランスクリプトーム / エピジェネティクス

Research Abstract

Whole transcriptome analyses were performed in a human and chimpanzee trio(father. mother. child) by quantifying mRNA level in each individual. Combined polymorphic information in parents and children with the amount of allele specific gene expression in children, we can quantify allele specific gene expression in children with known parental origin. The result reveals that around 17% of genes show allele biased expression in a chimpanzee child.

Research Products

• [Journal Article] Diversification of bitter taste receptor gene family in western chimpanzees (2011)
  • Author(s): Sugawara T, Go Y, Udono T, Morimura N, Tomonaga M, Hirai H, Imai H
  • Journal Title: Mol Biol Evol Volume: 28(2) Issue: 2 Pages: 921-931
  • DOI: 10.1093/molbev/msq279
  • Peer Reviewed
• [Journal Article] Diversification of bitter taste receptor gene family in western chimpanzees. (2011)
  • Author(s): Tohru Sugawara, ほか
  • Journal Title: Molecular Biology and Evolution Volume: 28 Pages: 921-931
  • Peer Reviewed
• [Journal Article] Identification of non-taster Japanese macaques for a specific bitter taste (2010)
  • Author(s): Suzuki N, Sugawara T, Matsui A, Go Y, Hirai H, Imai H
  • Journal Title: Primates Volume: 51(4) Issue: 4 Pages: 285-289
  • DOI: 10.1007/s10329-010-0209-3
  • Peer Reviewed
• [Journal Article] Degeneration of olfactory receptor gene repertories in primates : no direct link to full trichromatic vision. (2010)
  • Author(s): Atsushi Matsui, Yasuhiro Go
  • Journal Title: Mol. Biol. Evol Volume: 27 Issue: 5 Pages: 1192-1200
  • DOI: 10.1093/molbev/msq003
  • Peer Reviewed
• [Journal Article] Degeneration of olfactory receptor gene repertories in primates : no direct link to full trichromatic vision. (2010)
  • Author(s): Atsushi Matsui, ほか
  • Journal Title: Molecular Biology and Evolution Volume: 27 Pages: 1192-1200
  • Peer Reviewed
• [Journal Article] Identification of non-taster Japanese macaques for a specific bitter taste. (2010)
  • Author(s): Nami Suzuki, ほか
  • Journal Title: Primates Volume: 51 Pages: 285-289
  • Peer Reviewed
• [Presentation] チンパンジーの味覚に地域差はあるか?～分子遺伝学からの考察～ (2011)
  • Author(s): 早川卓志
  • Organizer: SAGA14
  • Place of Presentation: 熊本
  • Year and Date: 2011-11-12
• [Presentation] Comparative transcriptome and genome analysis in a chimpanzee trio (2011)
  • Author(s): Yasuhiro Go
  • Organizer: International Symposium of Developmental Systems Biologyon Gene Regulation and Aging
  • Place of Presentation: Shanghai, China
  • Year and Date: 2011-10-13
• [Presentation] Comparative transcriptome and genome analysis in a chimpanzee trio (2011)
  • Author(s): Yasuhiro GO
  • Organizer: International Symposium of Developmental Systems Biology on Gene Regulation and Aging
  • Place of Presentation: Shanghai, China(招待講演)
  • Year and Date: 2011-10-13
• [Presentation] コモンマーモセットにおける消化器系での味覚情報伝達物質の定量的解析 (2011)
  • Author(s): 権田彩
  • Organizer: 第45回味と匂い学会大会
  • Place of Presentation: 金沢
  • Year and Date: 2011-10-06
• [Presentation] Comparative transcriptome and genome analysis in a chimpanzee trio (2011)
  • Author(s): Yasuhiro GO
  • Organizer: Young Researchers Conference on Evolutionary Genomics
  • Place of Presentation: Tokyo(招待講演)
  • Year and Date: 2011-08-02
• [Presentation] Molecular Evolution of the Bitter Taste Receptor Gene Family in Three Chimpanzee Subspecies (2011)
  • Author(s): Takashi HAYAKAWA, ほか
  • Organizer: Young Researchers Conference on Evolutionary Genomics
  • Place of Presentation: Tokyo
  • Year and Date: 2011-08-01
• [Presentation] ニホンザルエキソーム解析-実験動物化にむけた遺伝的バックグラウンドの解明 (2011)
  • Author(s): 郷康広
  • Organizer: 日本進化学会第13回大会
  • Place of Presentation: 京都
  • Year and Date: 2011-07-30
• [Presentation] ニホンザルにおける地域特異的な苦味感受性変異 (2011)
  • Author(s): 鈴木南美
  • Organizer: 日本進化学会第13回大会
  • Place of Presentation: 京都
  • Year and Date: 2011-07-30
• [Presentation] チンパンジー3亜種における苦味受容体遺伝子ファミリーの分子進化 (2011)
  • Author(s): 早川卓志
  • Organizer: 日本進化学会第13回大会
  • Place of Presentation: 京都
  • Year and Date: 2011-07-30
• [Presentation] ニホンザルエキソーム解析～実験動物化にむけた遺伝的バックグラウンドの解明～ (2011)
  • Author(s): 郷康広, ほか
  • Organizer: 第13回日本進化学会
  • Place of Presentation: 京都市
  • Year and Date: 2011-07-30
• [Presentation] チンパンジー3亜種における苦味受容体遺伝子ファミリーの分子進化 (2011)
  • Author(s): 早川卓志, ほか
  • Organizer: 第13回日本進化学会
  • Place of Presentation: 京都市
  • Year and Date: 2011-07-30
• [Presentation] ニホンザルにおける地域特異的な苦味感受性変異 (2011)
  • Author(s): 鈴木南美, ほか
  • Organizer: 第13回日本進化学会
  • Place of Presentation: 京都市
  • Year and Date: 2011-07-30
• [Presentation] ゲノムを通して我が身を知る-ヒトとチンパンジーの間にあるもの (2011)
  • Author(s): 郷康広
  • Organizer: 第27回日本霊長類学会大会
  • Place of Presentation: 犬山
  • Year and Date: 2011-07-18
• [Presentation] ニホンザルエクソーム解析～実験動物化にむけた遺伝的バックグラウンドの解明～ (2011)
  • Author(s): 郷康広, ほか
  • Organizer: 第27回日本霊長類学会
  • Place of Presentation: 愛知県犬山市
  • Year and Date: 2011-07-18
• [Presentation] ゲノムを通して我が身を知る～ヒトとチンパンジーの間にあるもの～ (2011)
  • Author(s): 郷康広
  • Organizer: 第27回日本霊長類学会公開シンポジウム
  • Place of Presentation: 愛知県犬山市(招待講演)
  • Year and Date: 2011-07-18
• [Presentation] ニホンザルにおける苦味受容体TAS2R38の地域特異的な感受性変異 (2011)
  • Author(s): 鈴木南美
  • Organizer: 第27回日本霊長類学会大会
  • Place of Presentation: 犬山
  • Year and Date: 2011-07-17
• [Presentation] チンパンジー3亜種における苦味受容体遺伝子ファミリーの分子進化 (2011)
  • Author(s): 早川卓志
  • Organizer: 第27回日本霊長類学会大会
  • Place of Presentation: 犬山
  • Year and Date: 2011-07-17
• [Presentation] ニホンザルエクソーム解析-実験動物化にむけた遺伝的バックグラウンドの解明- (2011)
  • Author(s): 郷康広
  • Organizer: 第27回日本霊長類学会大会
  • Place of Presentation: 犬山
  • Year and Date: 2011-07-17
• [Presentation] ニホンザルにおける苦味受容体TAS2R38の地域特異的な感受性変異 (2011)
  • Author(s): 鈴木南美, ほか
  • Organizer: 第27回日本霊長類学会
  • Place of Presentation: 愛知県犬山市
  • Year and Date: 2011-07-17
• [Presentation] チンパンジー3亜種における苦味受容体遺伝子ファミリーの分子進化 (2011)
  • Author(s): 早川卓志, ほか
  • Organizer: 第27回日本霊長類学会
  • Place of Presentation: 愛知県犬山市
  • Year and Date: 2011-07-17
• [Presentation] 大型類人猿情報ネットワーク(GAIN)の活動:ウェブサイトでの情報管理 (2011)
  • Author(s): 落合-大平知美, ほか
  • Organizer: 第27回日本霊長類学会
  • Place of Presentation: 愛知県犬山市
  • Year and Date: 2011-07-17
• [Presentation] 霊長類における味覚受容体の進化 (2010)
  • Author(s): 郷康広
  • Organizer: 第82回日本遺伝学会
  • Place of Presentation: 札幌
  • Year and Date: 2010-09-22
• [Presentation] 霊長類における味覚受容体の進化 (2010)
  • Author(s): 郷康広, ほか
  • Organizer: 第82回日本遺伝学会
  • Place of Presentation: 札幌(招待講演)
  • Year and Date: 2010-09-22
• [Presentation] Evolutionary dynamics of bitter taste receptor gene repertoires in primates (2010)
  • Author(s): Yasuhiro Go
  • Organizer: European Chemoreception Research Organization XXth CONGRESS
  • Place of Presentation: Avignon, France
  • Year and Date: 2010-09-18
• [Presentation] DEGENERATION OF OLFACTORY RECEPTOR GENE REPERTORIES IN PRIMATES : NO DIRECT LINK TO FULL TRICHROMATIC VISION (2010)
  • Author(s): Atsushi Matsui, ほか
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto(招待講演)
  • Year and Date: 2010-09-16
• [Presentation] Evolutionary dynamics of bitter taste receptor gene repertoires in primates (2010)
  • Author(s): Yasuhiro Go, ほか
  • Organizer: European Chemoreception Research Organization XXth CONGRESS
  • Place of Presentation: Avignon, France(招待講演)
  • Year and Date: 2010-09-15
• [Presentation] REGION-SPECIFIC DISTRIBUTION OF NON-TASTER JAPANESE MACAQUES (2010)
  • Author(s): Nami Suzuki, ほか
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2010-09-14
• [Presentation] Comparative Transcriptome Analysis in Chimpanzee Trio. (2010)
  • Author(s): Yasuhiro Go, ほか
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto(招待講演)
  • Year and Date: 2010-09-13
• [Presentation] BITTER TASTE RECEPTORS OF PRIMATES. (2010)
  • Author(s): Hiroo Imai, ほか
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto(招待講演)
  • Year and Date: 2010-09-13
• [Presentation] DIVERSIFICATION OF BITTER TASTE RECEPTOR GENE FAMILY IN CHIMPANZEES (2010)
  • Author(s): Tohru Sugawara, ほか
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto(招待講演)
  • Year and Date: 2010-09-13
• [Presentation] INTRASUBSPECIFIC POLYMORPHISMS AND INTERSUBSPECIFIC DIVERGENECE OF BITTER TASTE RECEPTOR GENES IN CHIMPANZEES. (2010)
  • Author(s): Takashi Hayakawa, ほか
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto
  • Year and Date: 2010-09-13
• [Presentation] Genetic Polymorphismin Sensory Receptor Genesof Primates (2010)
  • Author(s): Nami Suzuki
  • Organizer: The 4th International Symposium of the Biodiversity and Evolution Global COE project
  • Place of Presentation: Kyoto
  • Year and Date: 2010-09-12
• [Presentation] チンパンジー亜種集団間における苦味受容体遺伝子配列の比較解 (2010)
  • Author(s): 早川卓志
  • Organizer: 第12回日本進化学会大会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-04
• [Presentation] チンパンジー亜種集団間における苦味受容体遺伝子配列の比較解析 (2010)
  • Author(s): 早川卓志, ほか
  • Organizer: 日本進化学会第12回東京大会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-04
• [Presentation] チンパンジー親子トリオトランスクリプトーム解析による遺伝子発現制御機構の解明 (2010)
  • Author(s): 郷康広
  • Organizer: 第12回日本進化学会
  • Place of Presentation: 東京
  • Year and Date: 2010-08-03
• [Presentation] チンパンジー親子トリオトランスクリプトーム解析による遺伝子発現制御機構の解明 (2010)
  • Author(s): 郷康広, ほか
  • Organizer: 日本進化学会第12回東京大会
  • Place of Presentation: 東京(招待講演)
  • Year and Date: 2010-08-03
• [Presentation] Comparative transcriptome analysis in a chimpanzee trio (2010)
  • Author(s): Yasuhiro Go
  • Organizer: Society Molecular Biology and Evolution
  • Place of Presentation: Lyon, France
  • Year and Date: 2010-07-07
• [Presentation] Comparative transcriptome analysis in a chimpanzee trio. (2010)
  • Author(s): Yasuhiro Go, ほか
  • Organizer: SMBE(国際分子進化生物学会)2010
  • Place of Presentation: Lyon, France
  • Year and Date: 2010-07-07
• [Presentation] Comparative transcriptome and genome analysis in a chimpanzee trio
  • Author(s): Yasuhiro Go
  • Organizer: Young Researchers Conferenceon Evolutionary Genomics
  • Place of Presentation: Tokyo
• [Presentation] Molecular Evolution of the Bitter Taste Receptor Gene Familyin Three Chimpanzee Subspecies
  • Author(s): Takashi Hayakawa
  • Organizer: Young Researchers Conferenceon Evolutionary Genomics
  • Place of Presentation: Tokyo
• [Presentation] DEGENERATION OF OLFACTORY RECEPTOR GENE REPERTORIES IN PRIMATES : NO DIRECT LINK TO FULL TRICHROMATIC VISION
  • Author(s): Atsushi Matsui
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto
• [Presentation] Comparative Transcriptome Analysisin Chimpanzee Trio
  • Author(s): Yasuhiro Go
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto
• [Presentation] Region-specific distribution of non-taster Japanes emacaques
  • Author(s): Nami Suzuki
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto
• [Presentation] DIVERSIFICATION OF BITTER TASTE RECEPTOR GENE FAMILY IN CHIMPANZEES
  • Author(s): Toru Sugawara
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto
• [Presentation] INTRASUBSPECIFIC POLYMORPHISMS AND INTERSUBSPECIFIC DIVERGENECE OF BITTER TASTE RECEPTOR GENES IN CHIMPANZEES
  • Author(s): Takashi Hayakawa
  • Organizer: International Primatological Society XXIII Congress
  • Place of Presentation: Kyoto
• [Book] Post Genome Biology of Primates (2012)
  • Author(s): Hirohisa Hirai, Hiroo Imai, Yasuhiro Go
  • Publisher: Primatology Monographs
• [Book] 受容体遺伝子の進化「化学受容の科学」 (2012)
  • Author(s): 郷康広
  • Publisher: 化学同人
• [Book] Post Genome Biology of Primates (Primatology Monographs) (2012)
  • Author(s): Hirohisa Hirai, Hiroo Imai, Yasuhiro Go
  • Total Pages: 316
  • Publisher: Springer-Verlag
• [Remarks]
  • URL: http://www.pri.kyoto-u.ac.jp/bunshi/idenshi/index.html
• [Remarks] 霊長類ゲノムデータベース(チンパンジー4個体のマイクロアレイデータを収蔵
  • URL: http://gcoe.biol.sci.kyoto-u.ac.jp/pgdb/
• [Remarks] 霊長類ゲノムデータベース(チンパンジー4個体のマイクロアレイデータを収蔵)
  • URL: http://gcoe.biol.sci.kyoto-u.ac.jp/pgdb/