Role of gut microbiota of Papuan for adaptation to low-protein diets

• Project/Area Number: 22770241
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Physical anthropology
• Research Institution: Jikei University School of Medicine
• Principal Investigator: IWASE Tadayuki 東京慈恵会医科大学, 医学部, 講師 (80385294)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 腸内細菌叢 / 低タンパク食適応 / 人類学 / 細菌学 / 腸内細菌 / 栄養学 / 適応・進化

Research Abstract

Nitrogen-fixing bacteria have been isolated from Papua people. These bacteria have been characterized by using biochemical tests, hydrogen generation, and growth in nitrogen-free media. In addition, these bacteria grow at 37 degree in nitrogen-free media under anaerobic conditions.

Research Products

• [Journal Article] Cloning, expression and purification of extracellular serine protease Esp, a biofilm-degrading enzyme, from Staphylococcus epidermidis (2011)
  • Author(s): S. Sugimoto, T. Iwase, F. Sato, A. Tajima, H. Shinji and Y. Mizunoe
  • Journal Title: Journal of Applied Microbiology Volume: 111 Pages: 1406-1415
• [Journal Article] Intranasal Application of S. epidermidis Prevents Colonization by Methicillin-Resistant Staphylococcus aureus in Mice (2011)
  • Author(s): B. Park, T. Iwase, GY. Li
  • Journal Title: PloS ONE Volume: 6 Issue: 10 Pages: e25880-e25880
  • DOI: 10.1371/journal.pone.0025880
  • Peer Reviewed
• [Journal Article] Staphylococcus epidermidis Esp inhibits Staphylococcus aureus biofilm formation and nasal colonization (2010)
  • Author(s): Iwase T., et al.
  • Journal Title: Nature Volume: 465 Pages: 346-349
  • Peer Reviewed
• [Journal Article] Isolation and identification of ATP-secreting bacteria from mice and humans (2010)
  • Author(s): Iwase T., et al.
  • Journal Title: J.Clin.Microbiol. Volume: 48 Pages: 1949-1951
  • Peer Reviewed
• [Journal Article] 病原細菌の定着を阻害する常在細菌の阻害因子の同定とその阻害メカニズムの解明 (2010)
  • Author(s): 岩瀬忠行, 水之江義充
  • Journal Title: 実験医学 Volume: 28 Pages: 2635-2638
• [Journal Article] 常在菌由来プロテアーゼによる病原性黄色ブドウ球菌のバイオフィルム形成阻害 (2010)
  • Author(s): 岩瀬忠行, 水之江義充
  • Journal Title: THE LUNG perspectives Volume: 18 Pages: 72-75
• [Presentation] ヒト-常在細菌-病原細菌との間に見られる相互作用 (2011)
  • Author(s): 岩瀬忠行
  • Organizer: 第94回日本細菌学会関東支部総会(2011年)
  • Place of Presentation: 北里大学(東京)
  • Year and Date: 2011-10-07
• [Presentation] ヒト-常在細菌-病原細菌との間に見られる相互作用 (2011)
  • Author(s): 岩瀬忠行
  • Organizer: 第94回日本細菌学会関東支部総会
  • Place of Presentation: 北里大学(東京)(招待講演)
  • Year and Date: 2011-10-07
• [Presentation] 常在細菌-病原細菌-宿主に見られる相互関係 (2011)
  • Author(s): 岩瀬忠行
  • Organizer: ポリアミン研究会
  • Place of Presentation: 東京慈恵会医科大学(東京)
  • Year and Date: 2011-09-10
• [Presentation] 常在細菌-病原細菌-宿主に見られる相互関係 (2011)
  • Author(s): 岩瀬忠行
  • Organizer: ポリアミン研究会
  • Place of Presentation: 東京慈恵会医科大学(東京)(招待講演)
  • Year and Date: 2011-09-10
• [Presentation] ワークショップ-ゲノムで繋がる微生物研究の新展開- (2011)
  • Author(s): 岩瀬忠行
  • Organizer: ゲノム微生物学会
  • Place of Presentation: 東北大学(宮城)
  • Year and Date: 2011-08-21
• [Presentation] 細菌と宿主の相互関係-複雑系における解析- (2011)
  • Author(s): 岩瀬忠行
  • Organizer: ゲノム微生物学会ワークショップ-ゲノムで繋がる微生物研究の新展開-
  • Place of Presentation: 東北大学(宮城県)(招待講演)
  • Year and Date: 2011-08-21
• [Presentation] 病原細菌・常在細菌-ヒトとの間に見られる相互作用 (2011)
  • Author(s): 岩瀬忠行
  • Organizer: 理研シンポジウム「微生物研究の潮流とそれを支えるリソース基盤」
  • Place of Presentation: 理化学研究所和光キャンパス
  • Year and Date: 2011-03-11
• [Presentation] 表皮ブドウ球菌による黄色ブドウ球菌の鼻腔定着阻害 (2010)
  • Author(s): 岩瀬忠行
  • Organizer: 高知大学医学部総合診療部院内感染対策セミナー(I)
  • Place of Presentation: 高知大学医学部キャンパス
  • Year and Date: 2010-11-04