Development of unnatural deoxy rare sugars using microbial enzymes
| Project/Area Number |
22780068
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | Kagawa University |
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Principal Investigator |
MORIMOTO Kenji 香川大学, 希少糖研究センター, 准教授 (90363184)
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| Project Period (FY) |
2009 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
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| Keywords | 希少糖 / デオキシ希少糖 / 異性化反応 / 物質生産 / 酵素利用 / 微生物 / 酵素 / 発酵 / 水素添加 / 微生物酸化 / 異性化 |
|---|
| Research Abstract |
6-Deoxy-D-psicose productivity was raised yield to 6.6% from 4.0% through the improvement in this study. The optimum L-rhamnose isomerase among a plenty of them was selected to produce from 6-deoxy-D-psicose to 6-Deoxy -D-allose. These results suggested that mass-production step of both rare deoxy sugars was established. Furthermore, the various isomerases reactivity for 6-deoxy-ketohexoses was overall investigated. For production of other deoxy sugars, two useful microbes was screened and then some enzymes relating rare sugars production was revealed basic properties.
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Report
(4 results)
Research Products
(74 results)
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[Journal Article] Eight stereoisomers of homonojirimycin from D-mannose.2012
Author(s)
Lenagh-Snow G.M., Jenkinson S.F., Newberry S.J., Kato A., Nakagawa S., Adachi I., Wormald M.R., Yoshihara A., Morimoto K., Akimitsu K., Izumori K., Fleet G.W.
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Journal Title
Org. Lett.
Volume: 14(8)
Pages: 2050-2053
Related Report
Peer Reviewed
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