| Project/Area Number |
22780079
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied microbiology
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| Research Institution | National Institute of Infectious Diseases |
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Principal Investigator |
UMEYAMA Takashi 国立感染症研究所, 生物活性物質部, 主任研究官 (20360696)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 微生物制御学 / 病原真菌 / 真菌症 / アスペルギルス症 / Aspergillus fumigatus / シグナル伝達 / プロテインキナーゼ / 細胞周期 / 糸状菌 |
|---|
| Research Abstract |
Overall mortality with invasive pulmonary aspergillosis was over 50%, leading to strong expectation for development of a novel therapeutics. Aim of study is to elucidate correlation between cell cycle regulation and filamentous growth via analysis of protein kinases in Aspergillus fumigatus, the major causative agent of aspergillosis. I analyzed 4 protein kinases by inhibitors, gene disruption, gene downregulation, and chemical genetics. I found that Aukl and Mps 1 are essential for the growth. These results could contribute to basic research for a novel therapeutics of aspergillosis and give a new insight of unique mechanism for cell cycle regulation into basic biology field.
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