| Project/Area Number |
22780085
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied biochemistry
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| Research Institution | Toyo University |
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Principal Investigator |
NEDACHI Taku 東洋大学, 生命科学部, 准教授 (50375200)
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
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| Keywords | 神経幹/前駆細胞 / ストレス応答 / 増殖因子 / 神経前駆細胞 / 物理的ストレス / 分化 / 神経幹細胞 / ストレス / 伸展 / シグナル伝達 / 成長因子 |
|---|
| Research Abstract |
Accumulated evidence suggests that the stress, including physical stress influence on neural progenitor cell fates, which resulted in various neuronal disorders. The aim of present study is to understand the underlying mechanisms how those stress, especially physical stresses, regulate NPC functions. Initially, because we found that the expression of progranulin(PGRN) is induced in response to those stresses, we analyzed and reported the effects of PGRN on NPC functions. We also found that nano materials induced physical stress on NPCs and controlled cellular functions.
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