| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2012: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Research Abstract |
To understand the role of histone deacetylase (HDAC) during meiosis, this study analyzed the biological and molecular function of Rpd3/HDAC, which is essential for progression of meiosis and sporulation in budding yeast. The results have revealed that Rpd3 regulates the nucleosome positioning at the promoter of the middle meiotic genes and it is required for the timely removal of the transcriptional repressor Sum1 to induce their transcription. In addition to this function, the data from this study suggest the possibility that Rpd3 functions at multiple steps during meiosis and sporulation.
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