Synthetic study on bioactive natural product, causing hatching phenomenon toward potato Cyst nematodes, by construction of highly-substituted cyclobutane skeleton
| Project/Area Number |
22780102
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | Nagoya University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 天然物化学 / 有機化学 / 合成化学 |
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| Research Abstract |
Synthesis of solanoeclepin A, the most active hatching agent of potato cyst nematode isolated from hydroponic potato cultures was examined not only for the chemical supply of solanoeclepin A but also for the structure-activity relationship study. As a result, the new ring expansion reaction was discovered for the synthesis of a chiral hexahydroazulene skeleton possessing an angular methyl group. Furthermore, synthesis of oxabicylo skeleton, corresponding to the left-hand nucleus, was also achieved.
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Report
(3 results)
Research Products
(68 results)
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[Presentation] Total Synthesis of Polygalolide A2011
Author(s)
Masaatsu Adachi, Hitomi Yamada, Minoru Isobe, Toshio Nishikawa
Organizer
The 6th International Conference on Cutting-edge Organic Chemistry in Asia(ICCEOCA-6), The 2nd New phase International Conference on Cutting-edge Organic Chemistry in Asia
Place of Presentation
Hong Kong, P. R. China
Related Report
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[Presentation] Total Synthesis of Polygalolide A2011
Author(s)
Masaatsu Adachi, Hitomi Yamada, Minoru Isobe, Toshio Nishikawa
Organizer
The 6th International Conference on Cutting-edge Organic Chemistry in Asia (ICCEOCA-6), The 2nd New phase International Conference on Cutting-edge Organic Chemistry in Asia
Place of Presentation
The Chinese University of Hong Kong (Hong Kong, P.R.China)
Related Report
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[Presentation] Synthetic Studies on Biologically Active Natural Products2010
Author(s)
oshio Nishikawa, Kumi Sugino, Atsuo Nakazaki, Keiko Higuchi, Masaatsu Adachi, Nopporn Thasana, Minoru Isobe
Organizer
The 9th NRCT-JSPS Joint Seminar 2010 "Natural Medicine Research for the Next Decade : New Challenges and Furture Collaboration
Place of Presentation
Bangkok, Thailan
Related Report
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[Presentation] Total Synthesis of Polygalolide A2010
Author(s)
Masaatsu Adachi, Hitomi Yamada, Minoru Isobe, Toshio Nishikawa
Organizer
The Pre-Symposium of 5th International Conference on Organic Chemistry in Asia
Place of Presentation
Kaohsiung, Taiwan
Related Report
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[Presentation] Synthetic Studies on Biologically Active Natural Products2010
Author(s)
Toshio Nishikawa, Kumi Sugino, Atsuo Nakazaki, Keiko Higuchi, Masaatsu Adachi, Nopporn Thasana, Minoru Isobe
Organizer
The 9th NRCT-JSPS Joint Seminar 2010 "Natural Medicine Research for the Next Decade : New Challenges and Furture Collaboration"
Place of Presentation
Bangkok, Thailand
Related Report
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