| Project/Area Number |
22780109
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Bioproduction chemistry/Bioorganic chemistry
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| Research Institution | The Institute of Physical and Chemical Research |
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Principal Investigator |
NAKAGAWA Yu 独立行政法人理化学研究所, 伊藤細胞制御化学研究室, 専任研究員 (90452284)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | Antibiotic / Carbohydrate recognition / Lectin / Natural product / Pradimicin / Solid-state NMR / Pradimicin A / 抗生物質 / 放線菌 / 糖受容体 / 天然物 / 固体NMR / 凝集 / 固相相互作用解析 |
|---|
| Research Abstract |
Pradimicins(PRMs) are natural antibiotics that recognize D-mannose(Man) in the presence of Ca^<2+> ion. In this study, a new strategy for analyzing molecular interaction of PRMs with Man in the solid state has been developed. The solid-state NMR analyses of the complexes of PRMs with Man revealed that PRMs bind Man in a Ca^<2+>-mediated manner, and successfully identified the Man binding site of PRMs.
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