| Project/Area Number |
22780110
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
|
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| Research Institution | Tohoku University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 大気環境刺激 / 皮膚脂質 / 酸化修飾 / スクアレン / 皮膚炎症 / スクワレン / 過酸化 / 食品 / 生理活性 / 分析 |
|---|
| Research Abstract |
When skin is exposed to air environment including sunlight, peroxidation of the skin surface lipids can occur. Indeed, we have previously found that peroxidation of squalene occurs in human skin surface lipids. In this study, we confirmed the findings (skin squalene peroxidation), and found that squalene hydroperoxide induces skin inflammatory responses. As a preventive strategy, the inflammation could be reduced via the use of rice tocotrienol. Squalene hydroperoxide (a peroxidation product of skin surface lipids)would therefore be considered a potential therapeutic target for skin inflammatory disorders, and tocotrienol has potential use as a protective agent against skin diseases.
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