Biological functions and mechanisms of vitamin D action on bone and mineral metabolism

Research Project

Project/Area Number	22780114
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Food science
Research Institution	The University of Tokyo
Principal Investigator	YAMAMOTO Yoko 東京大学, 分子細胞生物学研究所, 特任研究員 (30376644)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000) Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	ビタミンD / VDR / 骨代謝 / カルシウム代謝 / 転写制御 / 遺伝子改変マウス / 栄養化学
Research Abstract	The present study aims to find out biological functions and mechanisms of vitamin D action on bone and mineral metabolism. Osteoblast-specific VDRKO mice exhibited increased bone mass. These data indicated that VDR in osteoblasts is a negative regulator of bone mass control. Unlike systemic-VDRKO mice, AF-2 domain deleted VDR knock-in mice fed with high calcium diet exhibited hypocalcemia and impaired bone formation. These data indicated that unliganded VDR exerted negative effects on bone formation and mineral metabolism.

Report

(3 results)