Biological functions and mechanisms of vitamin D action on bone and mineral metabolism
| Project/Area Number |
22780114
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Food science
|
|---|
| Research Institution | The University of Tokyo |
|---|
Principal Investigator |
YAMAMOTO Yoko 東京大学, 分子細胞生物学研究所, 特任研究員 (30376644)
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
|---|
| Keywords | ビタミンD / VDR / 骨代謝 / カルシウム代謝 / 転写制御 / 遺伝子改変マウス / 栄養化学 |
|---|
| Research Abstract |
The present study aims to find out biological functions and mechanisms of vitamin D action on bone and mineral metabolism. Osteoblast-specific VDRKO mice exhibited increased bone mass. These data indicated that VDR in osteoblasts is a negative regulator of bone mass control. Unlike systemic-VDRKO mice, AF-2 domain deleted VDR knock-in mice fed with high calcium diet exhibited hypocalcemia and impaired bone formation. These data indicated that unliganded VDR exerted negative effects on bone formation and mineral metabolism.
|
Report
(3 results)
Research Products
(3 results)
