The analysis of prevention of gastrointestinal disease via intestinal epithelial receptor/transcriptional factor by food factor
| Project/Area Number |
22780115
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
SATSU Hideo 東京大学, 大学院・農学生命科学研究科, 助教 (80323484)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 食品機能 / 腸管上皮細胞 / aryl hydrocarbon receptor / pregnane X receptor / エクオール / ブロッコリースプラウト / 転写因子 / 食品因子 |
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| Research Abstract |
We analyzed the effect of food factors on the intestinal epithelial receptor/transcriptional factor and its related gastrointestinal disease. We found that hot water extracts of broccoli sprout significantly activated aryl hydrocarbon receptor(AhR) and further suppressed the formation of aberrant crypt foci in azoxymethane-induced colon cancer mouse model. We also found that equol, a soy isoflavone metabolite, could activate pregnane X receptor(PXR) which is one of the nuclear receptors and known to have anti-inflammatory effect. We further revealed that equol suppressed inflammatory response in dextran sulfate sodium-induced colitis of mouse. These results strongly suggest that food factors could prevent gastrointestinal diseases via activation of intestinal epithelial receptor/transcriptional factors.
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Report
(3 results)
Research Products
(50 results)
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[Journal Article] Induction of NAD(P) H : quinone oxidoreductase 1 expression by cysteine via Nrf2 activation in human intestinal epithelial LS180 cells2012
Author(s)
Satsu, H., Chidachi, E., Hiura, Y., Ogiwara, H., Gondo, Y., and Shimizu, M.
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Journal Title
Amino Acids, in press
Volume: (印刷中)
Issue: 4
Pages: 1547-1555
DOI
Related Report
Peer Reviewed
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[Journal Article] Metabolites of galangin by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin-inducible cytochrome P450 1A1 in human intestinal epithelial Caco-2 cells and their antagonistic activity toward aryl hydrocarbon receptor2010
Author(s)
Hamada, M., Satsu, H., Ashida, H., Sugita-Konishi, Y., and Shimizu, M.
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Journal Title
J. Agric. Food Chem.
Volume: 58(13)
Issue: 13
Pages: 8111-8118
DOI
Related Report
Peer Reviewed
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[Journal Article] Disaccharide derived from chondroitin sulfate A suppressed CpG-induced IL-6 secretion in macrophage-like J774. 1 cells.2010
Author(s)
Jin, M., Iwamoto, T., Yamada, K., Satsu, H., Totsuka, M., and Shimizu, M.
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Journal Title
Cytokine
Volume: 51(1)
Issue: 1
Pages: 53-59
DOI
Related Report
Peer Reviewed
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