| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Research Abstract |
We analyzed the effect of food factors on the intestinal epithelial receptor/transcriptional factor and its related gastrointestinal disease. We found that hot water extracts of broccoli sprout significantly activated aryl hydrocarbon receptor(AhR) and further suppressed the formation of aberrant crypt foci in azoxymethane-induced colon cancer mouse model. We also found that equol, a soy isoflavone metabolite, could activate pregnane X receptor(PXR) which is one of the nuclear receptors and known to have anti-inflammatory effect. We further revealed that equol suppressed inflammatory response in dextran sulfate sodium-induced colitis of mouse. These results strongly suggest that food factors could prevent gastrointestinal diseases via activation of intestinal epithelial receptor/transcriptional factors.
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