| Project/Area Number |
22780116
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Kyoto University (2011)
Gifu University (2010) |
|---|
Principal Investigator |
GOTO Tsuyoshi 京都大学, 生理化学研究ユニット, 特定助教 (10550311)
|
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 食品機能 / 脂肪細胞 / 分岐鎖アミノ酸 / ロイシン / 肥満 / アミノ酸 / インスリン |
|---|
| Research Abstract |
In the absence of insulin, leucine, one of branched-chain amino acids, suppresses triglyceride accumulation via the inhibition of glucose uptake in adipocytes, whereas it promotes the uptake of fatty acids in adipocytes in the presence of insulin. Moreover, the treatment for obese mice with leucine seems to improve the carbohydrate metabolism. These results indicated that leucine regulates whole body energy metabolism by the action on the organs, including white adipose tissue, depending on the nutrient state.
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