Prevention of obesity-related diseases by food components targeting at regulation of hypoxic response in adipocytes
| Project/Area Number |
22780121
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | University of Miyazaki |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 食品機能学 / 低酸素ストレス / 脂肪細胞 / Akt経路 / ERK経路 / 血管新生 |
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| Research Abstract |
Although obesity is characterized as enlargement of adipose tissue, effect of hypoxic stress induced by obesity on the function of adipocyte is still unknown. Here, we revealed that hypoxic stress stimulated the production of angiogenic factors and inflammatory cytokines accompanied with acceleration of lipid accumulation. In addition, as a result of signaling pathway analysis, hypoxic stress evoked activation of akt pathway. Taken together, as hypoxic stress evokes variety of phenotype in adipocytes, elucidation of hypoxia responsive signaling pathways which are responsible for induction of angiogenesis, inflammation would be helpful for the discovery of novel target for the prevention of obesity related diseases.
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Report
(3 results)
Research Products
(33 results)
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[Journal Article] Effect of highly lipolyzed goat cheese on HL-60 human leukemia cells : antiproliferative activity andinduction of apoptotic DNA damage
Author(s)
S Yasuda, H Kuwata, K Kawamoto, J Shirakawa, S Atobe, Y Hoshi, M Yamasaki, K Nishiyama, H Tachibana, K Yamada, H Kobayashi, K Igoshi.
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Journal Title
J. Dairy Sci
Volume: (in press)
Related Report
Peer Reviewed
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