Regulation of dopamine function by amino acid intake via modulation of tryptophan metabolism
| Project/Area Number |
22780123
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | The University of Shiga Prefecture |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 栄養学 / 脳・神経 / 食品 / 神経伝達物 / アミノ酸 / 脳機能 / 神経疾患 / 食事 / 神経伝達物質 |
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| Research Abstract |
The purpose of this study is to obtain findings for maintain brain function by diet. In vivo and in vitro, intake of branched chain amino acids, leucine or isoleucine suppressed production of tryptophan metabolite kynurenic acid, and enhanced release of neurotransmitter dopamine in rat brain. These results suggest that dietary manipulation of kynurenic production can modulate dopamine release in normal rage.
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Report
(3 results)
Research Products
(3 results)
