Regulation of dopamine function by amino acid intake via modulation of tryptophan metabolism

Research Project

Project/Area Number	22780123
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Food science
Research Institution	The University of Shiga Prefecture
Principal Investigator	FUKUWATARI Tsutomu 滋賀県立大学, 人間文化学部, 准教授 (50295630)
Project Period (FY)	2010 – 2011
Project Status	Completed (Fiscal Year 2011)
Budget Amount *help	¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000) Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000) Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords	栄養学 / 脳・神経 / 食品 / 神経伝達物 / アミノ酸 / 脳機能 / 神経疾患 / 食事 / 神経伝達物質
Research Abstract	The purpose of this study is to obtain findings for maintain brain function by diet. In vivo and in vitro, intake of branched chain amino acids, leucine or isoleucine suppressed production of tryptophan metabolite kynurenic acid, and enhanced release of neurotransmitter dopamine in rat brain. These results suggest that dietary manipulation of kynurenic production can modulate dopamine release in normal rage.

Report

(3 results)