| Project/Area Number |
22780126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
|
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | テロメラーゼ / カロテノイド / 相乗効果 / 癌 / ビタミンE / シグナル伝達 / 抗癌 |
|---|
| Research Abstract |
We screened potential telomerase inhibitors in food stuffs, and found that β-carotene, the most common carotenoid, significantly inhibited telomerase in cell-culture study. After treatment of the cells with β-carotene and vitamin E(α-tocopherol), telomerase activity was synergistically reduced. Furthermore, we ascertained the anti-telomerase action of β-carotene using in vivo tumor models.
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