Telomerase inhibition by carotenoid and its synergistic effect of other constituents in food stuffs.
| Project/Area Number |
22780126
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Food science
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| Research Institution | Nigata University of Phermacy and Applied Life Sciences |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | テロメラーゼ / カロテノイド / 相乗効果 / 癌 / ビタミンE / シグナル伝達 / 抗癌 |
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| Research Abstract |
We screened potential telomerase inhibitors in food stuffs, and found that β-carotene, the most common carotenoid, significantly inhibited telomerase in cell-culture study. After treatment of the cells with β-carotene and vitamin E(α-tocopherol), telomerase activity was synergistically reduced. Furthermore, we ascertained the anti-telomerase action of β-carotene using in vivo tumor models.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Efficient establishment of pig embryonic fibroblast cell lines with conditional expression of simian vacuolating virus 40 large T fragment2012
Author(s)
T. Fukuda, M. Katayama, T. Yoshizawa, T. Eitsuka, H. Mizukami, K. Nakagawa, H. Ito, H. Komagata, S. Song, S. Roh, Y. Hoshino, E. Sato, H. Hanada, K. Nishimori, T. Miyazawa, T. Uchida
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Journal Title
Biosci. Biotech. Biochem
Volume: (in press)
NAID
Related Report
Peer Reviewed
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