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Development of anti-aging foods

Research Project

Project/Area Number 22780128
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Food science
Research InstitutionChubu University

Principal Investigator

IIDA Machiko  中部大学, 生命健康科学研究所, 研究員 (60465515)

Project Period (FY) 2010-10-20 – 2013-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsアンチエイジング / 白髪 / 応用動物 / 薬剤選別 / 生理活性 / メラノサイト
Research Abstract

Since hair graying is a typical sign of aging, hair graying could be an excellent target to select anti-aging foods. However, decades are needed to analyze the dynamics of hair graying with aging in humans. Therefore, model mice that mimic the mechanism of hair graying in humans could be strong tools to develop anti-aging foods. In this study, we found a drug effective for hair graying using hair-graying model mice. Further studies are needed to clarify the similarities of hair graying mechanisms between the model mice and human to apply the anti-aging foods to human.

Report

(3 results)
  • 2013 Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (31 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (10 results) Patent(Industrial Property Rights) (7 results)

  • [Journal Article] Non-equilibrium atmospheric pressure plasmas modulate cell cycle-related gene expressions in melanocytic tumors of RET-transgenic mice.2014

    • Author(s)
      Yajima I, Iida M, Kumasaka MY, Omata Y, Ohgami N, Chang J, Ichihara S, Hori M, Kato M.
    • Journal Title

      Exp Dermatol

      Volume: 23 Issue: 6 Pages: 424-425

    • DOI

      10.1111/exd.12415

    • Related Report
      2013 Final Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Hearing impairments caused by genetic and environmental factors.2013

    • Author(s)
      Ohgami N, et al.
    • Journal Title

      Environ Health Prev Med.

      Volume: 18 Issue: 1 Pages: 10-15

    • DOI

      10.1007/s12199-012-0300-z

    • NAID

      10031143686

    • Related Report
      2013 Final Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic exposure to low frequency noise at moderate levels causes impaired balance in mice.2012

    • Author(s)
      Tamura H et al.
    • Journal Title

      PLoS One

      Volume: 7 Issue: 6 Pages: e39807-e39807

    • DOI

      10.1371/journal.pone.0039807

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] c-Ret-mediated hearing losses. Int J Clin Exp Pathol2012

    • Author(s)
      Ohgami N, Tamura H, Ohgami K, Iida M, et al
    • Journal Title

      e-Century Publishing Corporation

      Volume: 5(1) Pages: 23-38

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/?term=c-Ret-mediated+hearing+losses

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy.2012

    • Author(s)
      Ya manoshita O Kato M
    • Journal Title

      Dermatol Res Pract.

      Volume: 2012 Pages: 354191-354191

    • DOI

      10.1155/2012/354191

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] c-Ret-mediated hearing losses2012

    • Author(s)
      Ohgami N, Tamura H, Ohgami K, Iida M, Yajima I, Kumasaka MY, Goto Y, Sone M, Nakashima T, Kato M
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 5(1) Pages: 23-28

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sunlight exposure-mediated DNA damage in young adults. Cancer Epidemiol Biomarkers Prev2011

    • Author(s)
      Kato M, Iida M, et al
    • Journal Title

      American Association for Cancer Research

      Volume: 20(8) Issue: 8 Pages: 1622-1628

    • DOI

      10.1158/1055-9965.epi-11-0228

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing2011

    • Author(s)
      Ida-Eto M, Ohgami N, Iida M, et al
    • Journal Title

      J Biol Chem, American Society for Biochemistry and Molecular Biology

      Volume: 286(34) Issue: 34 Pages: 29621-29626

    • DOI

      10.1074/jbc.m111.236802

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects2011

    • Author(s)
      Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, et al
    • Journal Title

      Toxicol In Vitro, Elsevier

      Volume: 25(3) Issue: 3 Pages: 623-629

    • DOI

      10.1016/j.tiv.2010.12.012

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular Network Associated with MITF in Skin Melanoma Development and Progression.2011

    • Author(s)
      Ya manoshita O Kato M
    • Journal Title

      J Skin Cancer.

      Volume: 2011 Pages: 730170-730170

    • DOI

      10.1155/2011/730170

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Antioxidative effects of cherry leaves extract on tert-butyl hydroperocide-mediated cytotoxicity through regulation of thioredoxin-2 protein expression levels2011

    • Author(s)
      Taguchi N, Uemura N, Goto Y, Sakura M, Hara K, Niwa M, Iida M, Yanagishita T, Watanabe D, Kato M
    • Journal Title

      J Toxicol Environ Health A

      Volume: 74 Issue: 18 Pages: 1240-7

    • DOI

      10.1080/15287394.2011.570229

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] c-RET molecule in malignant melanoma from oncogenic RET-carrying transgenic mice and human cell lines2010

    • Author(s)
      Ohshima Y, Yajima I, Takeda K, Iida M, et al
    • Journal Title

      PLoS One, Public libraly of Science

      Volume: 5(4) Issue: 4 Pages: e10279-e10279

    • DOI

      10.1371/journal.pone.0010279

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A novel mouse model for de novo Melanoma2010

    • Author(s)
      Kumasaka MY, Yajima I, Hossain K, Iida M, et al
    • Journal Title

      Cancer Res, American Association for Cancer Research

      Volume: 70(1) Issue: 1 Pages: 24-9

    • DOI

      10.1158/0008-5472.can-09-2838

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice. European Journal of Dermatology

    • Author(s)
      Iida M, Yajima I, et al
    • Journal Title

      John Libbey Eurotext

      Volume: (In printing)

    • URL

      http://www.ncbi.nlm.nih.gov/pubmed/?term=Effects+of+non-thermal+atmospheric+pressure+plasma+irradiation+on+expression+levels+of+matrix+metalloproteinases+in+benign+melanocytic+tumors+in+RET-transgenic+mice

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] バリウムの発癌毒性2014

    • Author(s)
      飯田真智子、矢嶋伊知朗、熊坂真由子、大沼章子、神保 佳奈、田村青鳥、大神信孝、加藤昌志
    • Organizer
      第87回 日本産業衛生学会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] モデル動物を用いたメラノーマ予防・治療法の開発2014

    • Author(s)
      飯田真智子、矢嶋伊知朗、熊坂真由子、神保佳奈、田村青鳥、大神信孝、加藤昌志
    • Organizer
      第84回 日本衛生学会学術総会
    • Place of Presentation
      岡山コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Environmental stress and skin diseases2013

    • Author(s)
      Iida M
    • Organizer
      JSPS AA Science Platform Program : The 3rd International Symposium of Environmental Health Sciences in Hanoi University
    • Place of Presentation
      Vietnam
    • Year and Date
      2013-07-26
    • Related Report
      2013 Final Research Report
  • [Presentation] 動物モデルを用いた非熱的大気圧プラズマによる抗腫瘍効果の検討2013

    • Author(s)
      飯田真智子, 矢嶋伊知郎, 中川薫, 大神信孝, 近藤 博基, 竹田圭吾, 堀勝, 加納 浩之, 加藤昌志
    • Organizer
      第83回日本衛生学会 ポスター発表
    • Place of Presentation
      金沢大学
    • Related Report
      2013 Final Research Report
  • [Presentation] 動物モデルを用いた非熱的大気圧プラズマによる抗腫瘍効果の検討2013

    • Author(s)
      飯田真智子、矢嶋伊知郎、中川薫、大神信孝、近藤 博基、竹田圭吾、堀勝、加納 浩之、加藤昌志
    • Organizer
      第83回 日本衛生学会
    • Place of Presentation
      金沢大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] 毛乳頭はメラノサイトの避難小屋2012

    • Author(s)
      飯田 真智子, 田部 翔太, 猪原節ノ介, 松崎 貴
    • Organizer
      日本動物学会 第83回大会 第8回色素細胞シンポジウム
    • Place of Presentation
      大阪大学
    • Year and Date
      2012-09-13
    • Related Report
      2013 Final Research Report
  • [Presentation] 日常的な日光曝露がDNA酸化損傷に与える影響-疫学的検討-2012

    • Author(s)
      飯田真智子、田巻満里絵、後藤友二、矢嶋伊知郎、加藤昌志
    • Organizer
      第82回日本衛生学会学術総会
    • Place of Presentation
      京都大学吉田キャンパス(京都府)
    • Year and Date
      2012-03-25
    • Related Report
      2011 Annual Research Report
  • [Presentation] Skin pigmentation and urinary 8-OHdG levels in humans2012

    • Author(s)
      M Iida, I. Yajima, N. Ohgami, M. Tamaki, M. Kato
    • Organizer
      The 25th Annual meeting of The Japanese Society for Pigment Research
    • Place of Presentation
      長浜バイオ大学 滋賀県
    • Related Report
      2013 Final Research Report
  • [Presentation] 日常的な日光曝露がDNA酸化損傷に与える影響 -疫学的検討-2012

    • Author(s)
      飯田真智子, 加藤昌志, 後藤友二, 近藤高明, 矢嶋伊知朗
    • Organizer
      衛生学会2012年第82回
    • Place of Presentation
      京都大学
    • Related Report
      2013 Final Research Report
  • [Presentation] Aging and skin biology2010

    • Author(s)
      Iida M
    • Organizer
      JSPS AA Science Platform Program : The 1st International Symposium of Environmental Health Sciences in Chubu University
    • Place of Presentation
      Japan
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 白毛数抑制剤及び非治療的な美容方法2012

    • Inventor(s)
      田口 暢彦, 加藤昌志, 飯田真智子, 上村 規行
    • Industrial Property Rights Holder
      ホーユー(株), 学校法人中部大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-276617
    • Filing Date
      2012-12-19
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 加齢性白髪のモデル動物2012

    • Inventor(s)
      加藤昌志, 飯田真智子
    • Industrial Property Rights Holder
      学校法人中部大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2012-010573
    • Filing Date
      2012-01-23
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 加齢性白髪のモデル動物2012

    • Inventor(s)
      加藤昌志、飯田真智子
    • Industrial Property Rights Holder
      中部大学
    • Industrial Property Number
      2012-010573
    • Filing Date
      2012-01-23
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 色素細胞性疾患のモデル動物及びその用途2011

    • Inventor(s)
      加藤昌志, 飯田真智子
    • Industrial Property Rights Holder
      学校法人中部大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2011-253454
    • Filing Date
      2011-11-21
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 白毛の予防・治療剤, 非治療的な美容方法,エンドセリンレセプターB遺伝子発現促進剤及びMITF-M遺伝子発現促2011

    • Inventor(s)
      加藤昌志, 飯田真智子, 上村 規行, 田口 暢彦
    • Industrial Property Rights Holder
      ホーユー(株), 学校法人中部大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2011-129093
    • Filing Date
      2011-06-09
    • Related Report
      2013 Final Research Report
  • [Patent(Industrial Property Rights)] 色素細胞性疾患のモデル動物及びその用途2011

    • Inventor(s)
      加藤昌志、飯田真智子
    • Industrial Property Rights Holder
      中部大学
    • Industrial Property Number
      2011-253454
    • Filing Date
      2011-11-21
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 薬剤評価方法2010

    • Inventor(s)
      加藤昌志, 飯田真智子, 熊坂真由子, 矢嶋伊知朗, 田口 暢彦
    • Industrial Property Rights Holder
      ホーユー(株), 学校法人中部大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2010-145179
    • Filing Date
      2010-06-25
    • Related Report
      2013 Final Research Report

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Published: 2010-11-30   Modified: 2019-07-29  

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