The role of fatty acid binding protein 3 in life-style related diseases

• Project/Area Number: 22780129
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Food science
• Research Institution: Chubu University
• Principal Investigator: KUSUDO Tatsuya 中部大学, 生命健康科学部, 助手 (00460535)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: FABP3 / 糖脂質代謝 / 生活習慣病 / 輸送タンパク質 / FABP / 骨格筋代謝制御 / AS160

Research Abstract

Fatty acid binding protein 3 is an intracellular translocator of lipids. We have investigated the relationship between FABP3 expression and life-style related diseases. In this study, we showed that an increase in FABP3 expression in C2C12 myotube stimulates AS160 phosphorylation and glucose uptake via AMPK activation. And we also identified several proteins that interact with FABP3.

Research Products

• [Journal Article] Fatty acid-binding protein 3 stimulates glucose uptake by facilitating AS160 phosphorylation in mouse muscle cells (2011)
  • Author(s): Kusudo T, Kontani Y, Kataoka N, Ando F, Shimokata H, Yamashita H
  • Journal Title: Genes to Cells Volume: 16(6) Pages: 681-691
  • Peer Reviewed
• [Journal Article] Fatty acid-binding protein 3 stimulates glucose uptake by facilitating A S160 phosphorylation in mouse muscle cells (2011)
  • Author(s): Kusudo tatsuya
  • Journal Title: Genes to Cells Volume: 16(6) Pages: 681-691
  • Peer Reviewed
• [Presentation] 骨格筋のエネルギー代謝における脂肪酸結合タンパク質3の役割の検討 (2012)
  • Author(s): 楠堂達也
  • Organizer: 日本農芸化学会
  • Place of Presentation: 京都女子大学
  • Year and Date: 2012-03-25
• [Presentation] 骨格筋の細胞内代謝における脂肪酸結合タンパク質3の役割の検討 (2012)
  • Author(s): 楠堂達也、片岡直也、山下均
  • Organizer: 日本農芸化学会2012大会
  • Place of Presentation: 京都
• [Presentation] 骨格筋のエネルギー代謝における脂肪酸結合タンパク質3の役割の検討 (2011)
  • Author(s): 楠堂達也
  • Organizer: 日本肥満学会
  • Place of Presentation: 淡路夢舞台国際会議場
  • Year and Date: 2011-09-23
• [Presentation] 生活習慣病の発症における脂肪酸結合タンパク質3の役割の検討 (2011)
  • Author(s): 楠堂達也、片岡直也、山下均
  • Organizer: 第31回日本肥満学会
  • Place of Presentation: 淡路島
• [Presentation] 生活習慣病の発症における脂肪酸結合タンパク質3の役割の検討 (2010)
  • Author(s): 楠堂達也、片岡直也、山下均
  • Organizer: 第33回日本分子生物学会年会
  • Place of Presentation: 神戸