Development of vaccine against Oncorhynchus masou virus(OMV) disease based on whole genome analysis of OMV
| Project/Area Number |
22780168
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General fisheries
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| Research Institution | Hokkaido University |
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Principal Investigator |
KASAI Hisae 北海道大学, 大学院・水産科学研究院, 准教授 (50399995)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 魚病 / 増養殖 / 魚類ウイルス / 癌ウイルス / ワクチン / ゲノムワイド解析 |
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| Research Abstract |
Oncorhynchus masouvirus(OMV) disease is a hepatitic, oncogenic and skin ulcerative condition of national and international socio-economic importance. The OMV genome sequences of three strains including the high virulent strain against rainbow trout revealed about 160 kbp genome composed of a unique long sequence, and a unique short fragment flanked by inverted repeats. ORFs involved in pathogenicity or oncogenicity were found in OMV genome. Furthermore an effective vaccine was developed in which relative percent survival(RPS) reached 74%.
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Report
(3 results)
Research Products
(27 results)
