Studies on acute immune responses against dsRNA in Pacific oyster
| Project/Area Number |
22780169
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General fisheries
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| Research Institution | Tohoku University |
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Principal Investigator |
ITOH Naoki 東北大学, 大学院・農学研究科, 助教 (30502736)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 生理 / 生体防御 / パターン認識受容体 / 病原体関連分子パターン / 二枚貝 / 自然免疫 / 二本鎖RNA / RNA干渉法 / レクチン / リゾチーム / 生体防御反応 / 血球 / 二本差RNA / 遺伝子発現 |
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| Research Abstract |
Recently, it has been known that bivalve mollusks possess immune recognition systems against foreign materials. This study revealed that the Pacific oyster increased hemocyte numbers as immune reactions to dsRNA which represents virus invasion. On the other hand, another bivalve species, the Manila clam, does not show this response, suggesting that there are variations of dsRNA recognition systems among bivalve species. Moreover, the Manila clam without apparent responses against dsRNA is considered to be an ideal model organism for RNA inference experiments by dsRNA, and currently we conduct optimizationand standardization of RNAi for the clam host defense studies.
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Report
(4 results)
Research Products
(2 results)
