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Molecular mechanisms of host recognition of Heterobothrium okamotoi

Research Project

Project/Area Number 22780171
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field General fisheries
Research InstitutionThe University of Tokyo

Principal Investigator

TASUMI Satoshi  東京大学, 大学院・農学生命科学研究科, 特任助教 (90359646)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords魚病 / 寄生虫 / 宿主特異性 / トラフグ / 鰓 / 細胞表面ディスプレイ / 膜タンパク質 / サブトラクティブPCR / レクチン / リガンド-レセプター相互作用
Research Abstract

Heterobothrium okamotoi, a parasite specific to Takifugu rubripes, does not parasitize to relative species T. niphobles. The aim of this study is to identify the molecule underlying this phenomenon. At first we established the technique, which enable insect cells to display T. rubripes membrane proteins at the cell surface. By using this technique, we tried to identify the molecule(s), which is a receptor(s) for ligand(s) localizing at the surface of H. okamotoi, but it was not successful. At the same time, we searched genes expressed at different level in gills of T. rubripes and T. niphobles, and found a couple of candidates. One of the candidates is pufflectin, which is an immune related factor we originally found in the skin mucus of T. rubripes. H. okamotoi might use this molecule to recognize its host.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (2 results)

All 2012 2011

All Presentation (2 results)

  • [Presentation] フグ類鰓におけるパフレクチン発現量の種間差と寄生虫宿主特異性2012

    • Author(s)
      山口晶、田角聡志、筒井繁行、中村修、菊池潔、鈴木譲
    • Organizer
      平成24年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学(東京都)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report 2011 Final Research Report
  • [Presentation] 魚類膜タンパク質の細胞表面ディスプレイ法の開発2011

    • Author(s)
      田角聡志、小林啓介、筒井繁行、中村修、鈴木譲
    • Organizer
      平成23年度日本水産学会春季大会
    • Place of Presentation
      東京海洋大学(東京都)
    • Year and Date
      2011-03-28
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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