Research Project
Grant-in-Aid for Young Scientists (B)
To elucidate whether cell-mediated immunity and/or humoral immunity contribute to protection against Edwardsiella tardainfection in fish, we examined T-cell related gene expression, specific antibody titers, bacterial clearance, and adoptive transfer of immunized lymphocyte subsets. Our results indicate that cell mediated immunity play an important roles in the protection against E. tardainfection in fish. In addition, cytotoxic T lymphocytes are crucial player in protecting fish from E. tardainfection.Subsequently, we have cloned T-cell related genes from yellowtail. Using these genes as a marker, vaccine efficacy of inactivated vaccine against mycobacteriosis was evaluated. Inactivated vaccine with adjuvant induced cell-mediated immune response, although inactivated cells enhanced humoral immunity in yellowtail.
All 2013 2012 2011 2010
All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (24 results)
Fisheries Science
Volume: 79巻 Issue: 2 Pages: 213-220
10.1007/s12562-012-0590-5
Carassius auratus langsdorfii. Veterinary Immunology and Immunopathology
Volume: 153巻 Issue: 1-2 Pages: 83-90
10.1016/j.vetimm.2013.02.004
水産増殖
Volume: 60 Pages: 405-410
10031122373
Developmental & Comparative Immunology
Volume: 35 Issue: 1 Pages: 88-93
10.1016/j.dci.2010.08.010
Dev. Comp. Immunol
Volume: 35 Issue: 6 Pages: 650-660
10.1016/j.dci.2011.01.013
Fish Pathology
Volume: 46 Issue: 3 Pages: 80-86
10.3147/jsfp.46.80
10029692326
J.Biochem.
Volume: 150 Issue: 5 Pages: 501-514
10.1093/jb/mvr085
Developmental and Comparative Immunology
Volume: 35 Pages: 88-93
Volume: 35 Pages: 650-660
