Basic research in regulatory pathway of teleost for amino acid

• Project/Area Number: 22780194
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Fisheries chemistry
• Research Institution: Tokyo University of Marine Science and Technology (2011); Gunma National College of Technology (2010)
• Principal Investigator: NAGASAKA Reiko 東京海洋大学, 海洋科学部, 助教 (90444132)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 代謝・酵素 / 代謝制御因子 / アミノ酸代謝 / TOR / PPAR / ラパマイシン

Research Abstract

Fish has been considered as glucose intolerant. Because they depend on amino acid for production of their energy, it is to be anticipated that they have sensitive amino acid sensor system. However, there are few reports about amino acid control regulation system of teleost. This research investigated regulatory pathway of teleost for amino acid. As a result, there were regulatory pathways of teleost for amino acid same as mammal. Some factors which also existed in mammal played important role for amino acid metabolism of teleost.

Research Products

• [Journal Article] γ-オリザノールの添加がアスタキサンチン含有飼料によるブリ切り身の変色抑制作用に及ぼす影響 (2011)
  • Author(s): 長阪玲子, 風間貴充, 潮秀樹, 坂本浩志, 坂本憲一
  • Journal Title: 日本水産学会誌 Volume: 77 Pages: 1101-1104
  • NAID: 10029654246
  • Peer Reviewed
• [Journal Article] Expressed sequence tag analysis on adipose tissue of rainbow trout Oncorhynchus mykiss and tissue distribution of adiponectin (2011)
  • Author(s): Hidehiro Kondo, Ryota Suga, Satomitsu Suda, Reiko Nozaki, Ikuo Hirono, Reiko Nagasaka, Gen Kaneko, Hideki Ushio, Shugo Watabe
  • Journal Title: Gene Volume: 485 Pages: 40-45
  • Peer Reviewed
• [Journal Article] Accumulation of gamma-oryzanol in teleost (2011)
  • Author(s): Reiko Nagasaka, Takamitsu Kazama, Hideki Ushio, Hiroshi Sakamoto, Kenichi Sakamoto, Shuichi Satoh
  • Journal Title: Fish. Sci Volume: 77 Pages: 431-438
  • NAID: 10028110625
  • Peer Reviewed
• [Journal Article] Biological abilities of rice bran-derived antioxidant phytochemicals for medical therapy (2011)
  • Author(s): Md Shafiqul Islam, Reiko Nagasaka, Kazuyuki Ohara, Takamitsu Hosoya, Hiroshi Ozaki, Hideki Ushio, Masatoshi Hori
  • Journal Title: Current Topics in Medical Chemistry Volume: 11 Pages: 1847-1853
  • Peer Reviewed
• [Journal Article] γ-Oryzanol recovers mouse hypoadiponectinemia induced by animal fat ingestion (2011)
  • Author(s): Reiko Nagasaka, Tomoteru Yamsaki, Asako Uchida, Kazuyuki Ohara, Hideki Ushio
  • Journal Title: Phytomedicine Volume: 18 Pages: 655-660
  • Peer Reviewed
• [Journal Article] Oral administration ofγ-aminobutyric acid andγ-oryzanol prevents stress-induced hypoadiponectinemia (2011)
  • Author(s): Kazuyuki Ohara, Yuka Kiyotani, Asako Uchida, Reiko Nagasaka, Hiroyuki Maehara, Shigeharu Kanemoto, Masatoshi Hori, Hideki Ushio
  • Journal Title: Phytomedicine Volume: 18 Pages: 669-671
  • Peer Reviewed
• [Journal Article] Accumulation of gamma-oryzanol in teleost (2011)
  • Author(s): Reiko Nagasaka, Takamitsu Kazama, Hideki Ushio, Hiroshi Sakamoto, Kenichi Sakamoto, Shuichi Satoh
  • Journal Title: Fisheries Science Volume: Vol.77 Pages: 431-438
  • NAID: 10028110625
  • Peer Reviewed
• [Journal Article] γ-Oryzanol recovers mouse hypoadiponectinemia induced by animal fatingestion
  • Author(s): Reiko Nagasaka, Tomoteru Yamsaki, Asako Uchida, Kazuyuki Ohara, Hideki Ushio
  • Journal Title: Phytomedicine Volume: (in press)
  • Peer Reviewed
• [Journal Article] Oral administration of γ-aminobutyric acid and γ-oryzanol prevents stress-induced hypoadiponectinemia
  • Author(s): Kazuyuki Ohara, Yuka Kiyotani, Asako Uchida, Reiko Nagasaka, Hiroyuki Maehara, Shigeharu Kanemoto, Masatoshi Hori, Hideki Ushio
  • Journal Title: Phytomedicine Volume: (in press)
  • Peer Reviewed
• [Presentation] 発現配列タグ(EST)を利用したトラフグおよびマダイのアポリポタンパク質の発現様式の比較 (2011)
  • Author(s): 金子元,近藤秀裕,廣野育生,長阪玲子,佐藤秀一,潮秀樹,渡部終五
  • Organizer: 平成23年度日本水産学会秋季大会
  • Place of Presentation: 長崎大学
  • Year and Date: 2011-09-29
• [Presentation] 発現配列タグ(EST)を利用したトラフグおよびマダイのアポリポタンパク質の発現様式の比較 (2011)
  • Author(s): 金子元, 近藤秀裕, 廣野育生, 長阪玲子, 佐藤秀一, 潮秀樹, 渡部終五
  • Organizer: 平成23年度日本水産学会秋季大会
  • Place of Presentation: 長崎大学(長崎県)
  • Year and Date: 2011-09-29
• [Presentation] Regulatory mechanisms of amino acid metabolism in teleost (2011)
  • Author(s): Reiko Nagasaka, Mizuki Ueki, Hidehiro Kondo, Ikuo Hirono, Gen Kaneko, Shugo Watabe, Hideki Ushio
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2011-09-22
• [Presentation] Regulatory mechanisms of amino acid metabolism in teleost (2011)
  • Author(s): Reiko Nagasaka, Mizuki Ueki, Hidehiro Kondo, Ikuo Hirono, Gen Kaneko, Shugo Watabe, Hideki Ushio
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都国際会館(京都府)
  • Year and Date: 2011-09-22
• [Presentation] 魚類におけるアミノ酸代謝の制御機構に関する基礎研究2 (2011)
  • Author(s): 植木瑞葵, 長阪玲子, 近藤秀裕, 廣野育生, 金子元, 渡部終五, 潮秀樹
  • Organizer: 平成23年度日本水産学会春季大会
  • Place of Presentation: 東京海洋大学
  • Year and Date: 2011-03-30
• [Presentation] 魚類におけるアミノ酸代謝の制御機構に関する基礎研究2 (2011)
  • Author(s): 植木瑞葵,長阪玲子,近藤秀裕,廣野育生,金子元,渡部終五,潮秀樹
  • Organizer: 平成23年度日本水産学会春季大会
  • Year and Date: 2011-03-27
• [Presentation] γオリザノール投与が魚類の代謝制御に及ぼす影響 (2011)
  • Author(s): 風間貴充,長阪玲子,近藤秀裕,廣野育生,佐藤秀一,韓ユナ,金子元,渡部終五,潮秀樹
  • Organizer: 平成23年度日本水産学会春季大会
  • Year and Date: 2011-03-27
• [Presentation] ニジマス筋肉および肝臓におけるアディポネクチン発現分布 (2011)
  • Author(s): 韓ユナ,金子元,渡部終五,潮秀樹,長阪玲子,近藤秀裕,廣野育生
  • Organizer: 平成23年度日本水産学会春季大会
  • Year and Date: 2011-03-27
• [Presentation] Regulation of peroxisome proliferator activated receptor activity by targetof rapamycin and amino acids in teleost (2010)
  • Author(s): 長阪玲子,植木瑞葵,飯野翔太,潮秀樹,近藤秀裕,廣野育生,金子元,渡部終五
  • Organizer: BMB2010
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-12-07
• [Presentation] Regulation of peroxisome proliferator-activated receptor activity by target of rapamycin and amino acids in teleost (2010)
  • Author(s): 長阪玲子, 植木瑞葵, 飯野翔太, 潮秀樹, 近藤秀裕, 廣野育生, 金子元, 渡部終五
  • Organizer: BMB2010
  • Place of Presentation: 神戸国際展示場
  • Year and Date: 2010-12-07
• [Presentation] 魚類におけるアミノ酸代謝の制御機構に関する基礎研究 (2010)
  • Author(s): 長阪玲子,植木瑞葵,潮秀樹,近藤秀裕,廣野育生,金子元,渡部終五
  • Organizer: 平成22年度日本水産学会秋季大会
  • Place of Presentation: 京都大学
  • Year and Date: 2010-09-23