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Physiological roles of ARF1 mRNA interacting with insulin receptor substrates

Research Project

Project/Area Number 22780249
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Applied animal science
Research InstitutionHiroshima University (2011)
The University of Tokyo (2010)

Principal Investigator

TOSHIAKI Fukushima  広島大学, 大学院・医歯薬学総合研究科, 助教 (70543552)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords代謝 / 内分泌制御 / シグナル伝達 / 発現制御 / 核酸 / タンパク質 / 応用動物
Research Abstract

We have previously found that insulin receptor substrates(IRSs), mediators of insulin/ insulin-like growth factors(IGFs) signals, are associated with RNA. In this study, we investigated roles of the complexes. Results suggest that IRSs play multiple roles ; 1) they promote small nucleolar RNA(snoRNA) biogenesis, leading to enhanced ribosomal maturation/ activation, and 2) they regulate internal ribosome entry site(IRES)-mediated translation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (35 results)

All 2012 2011 2010 Other

All Journal Article (16 results) (of which Peer Reviewed: 16 results) Presentation (16 results) Remarks (3 results)

  • [Journal Article] Phosphatidylinositol 3-kinase-binding protein, PI3KAP/XB130, is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells2012

    • Author(s)
      Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F, Takahashi S-I.
    • Journal Title

      Mol Endocrinol

      Volume: 26 Issue: 6 Pages: 1043

    • DOI

      10.1210/me.2011-1349

    • URL

      https://pure.teikyo.jp/en/publications/254fca99-f326-4f51-8a6b-d8a15608a27f

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation2012

    • Author(s)
      Kawashima Y, Higaki K, Fukushima T, Hakuno F, Nagaishi JI, Hanaki K, Nanba E, Takahashi SI, Kanzaki S
    • Journal Title

      Clin.Endocrinol.

      Volume: (in press) Issue: 2 Pages: 246-54

    • DOI

      10.1111/j.1365-2265.2012.04357.x

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development2012

    • Author(s)
      Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
    • Journal Title

      Arterioscler Thromb Vasc Biol

      Volume: 32 Issue: 2 Pages: 291-298

    • DOI

      10.1161/atvbaha.111.234559

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes.2012

    • Author(s)
      Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
    • Journal Title

      American Journal of Physiology - Endocrinology and Metabolism

      Volume: 302 Issue: 3 Pages: 286-296

    • DOI

      10.1152/ajpendo.00324.2011

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Phosphatidylinositol 3-Kinase Binding Protein, PI3KAP/XB130 is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells2012

    • Author(s)
      山中大介, 福嶋俊明, 他
    • Journal Title

      Endocrinology

      Volume: (印刷中)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells2011

    • Author(s)
      Fukushima T, Okajima H, Yamanaka D, Ariga M, Nagata S, Ito A, Yoshida H, Asano T, Chida K
    • Journal Title

      Mol.Cell Endocrinol.

      Volume: 344 Issue: 1-2 Pages: 81-90

    • DOI

      10.1016/j.mce.2011.06.029

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011

    • Author(s)
      Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
    • Journal Title

      J Biol Chem

      Volume: 286 Issue: 23 Pages: 20812-20822

    • DOI

      10.1074/jbc.m110.206904

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity2011

    • Author(s)
      Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
    • Journal Title

      Am J Physiol Cell Physiol

      Volume: 300(5) Issue: 5 Pages: 1047-54

    • DOI

      10.1152/ajpcell.00416.2010

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases2011

    • Author(s)
      Fukushima T, Arai T, Ariga M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Hakuno F, Takahashi S-I
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 404 Issue: 3 Pages: 767-773

    • DOI

      10.1016/j.bbrc.2010.12.045

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis2011

    • Author(s)
      中津祐介、福嶋俊明, 他
    • Journal Title

      The Journal of biological chemistry

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity.2011

    • Author(s)
      大野晴也、福嶋俊明, 他
    • Journal Title

      American Journal of Physiology-Cell Physiology

      Volume: (In press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin insulin-like growth factor-I receptor tyrosine kinases.2011

    • Author(s)
      福嶋俊明, 他
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 404(3) Pages: 767-73

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity2010

    • Author(s)
      Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T.
    • Journal Title

      J. Biol. Chem

      Volume: 285 Issue: 43 Pages: 33018-33027

    • DOI

      10.1074/jbc.m110.137836

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paraquat-induced oxidative stressrepresses phosphatidyl inositol 3-kinaseactivities leading to impaired glucoseuptake in 3T3-L1 adipocytes2010

    • Author(s)
      柴田倫宏、福嶋俊明(5番目)他12名
    • Journal Title

      The Journalof biological chemistry

      Volume: 285 Issue: 27 Pages: 20915-25

    • DOI

      10.1074/jbc.m110.126482

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity.2010

    • Author(s)
      中津祐介、福嶋俊明, 他
    • Journal Title

      The Journal of biological chemistry

      Volume: 285(43) Pages: 33018-27

    • NAID

      120006471211

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes.2010

    • Author(s)
      柴田倫宏、福嶋俊明, 他
    • Journal Title

      The Journal of biological chemistry

      Volume: 285(27) Pages: 20915-25

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Roles of peptidyl-prolyl cis/ trans isomerase NIMA-interacting 1 in non-alcoholicstea tohepatitis.2011

    • Author(s)
      中津祐介福嶋俊明, 他
    • Organizer
      日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Roles of peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 in non-alcoholic steatohepatitis2011

    • Author(s)
      中津祐介, 福嶋俊明, 他
    • Organizer
      日本生化学会
    • Place of Presentation
      京都市
    • Year and Date
      2011-09-24
    • Related Report
      2011 Annual Research Report
  • [Presentation] Nedd4 potentiates insulin signals through ubiquitination of IRS-2 in hepatocytes.2011

    • Author(s)
      福嶋俊明他
    • Organizer
      日本生化学会
    • Place of Presentation
      京都
    • Year and Date
      2011-09-23
    • Related Report
      2011 Final Research Report
  • [Presentation] Nedd4 potentiates insulin signals through ubiquitination of IRS-2 in hepatocytes2011

    • Author(s)
      福嶋俊明, 他
    • Organizer
      日本生化学会
    • Place of Presentation
      京都市
    • Year and Date
      2011-09-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ubiquitination of insulin receptor substrate by Nedd4 potentiates insulin/ IGF signals.2011

    • Author(s)
      福嶋俊明他
    • Organizer
      日本生化学会中国四国支部会
    • Place of Presentation
      広島
    • Year and Date
      2011-05-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Ubiquitination of insulin receptor substrate by Nedd4 potentiates insul in/IGF signals2011

    • Author(s)
      福嶋俊明, 他
    • Organizer
      日本生化学会中国四国支部会
    • Place of Presentation
      広島市
    • Year and Date
      2011-05-14
    • Related Report
      2011 Annual Research Report
  • [Presentation] PGAM5, aserine/ threonine phosphatase associating with IRS, is required for the enhancement of insulin response.2011

    • Author(s)
      鋳延淳一福嶋俊明他
    • Organizer
      日本内分泌学会
    • Place of Presentation
      神戸
    • Year and Date
      2011-04-22
    • Related Report
      2011 Final Research Report
  • [Presentation] PGAM5, a serine/threonine phosphatase associating with IRS, is required for the enhancement of insulin response2011

    • Author(s)
      鋳延淳一, 福嶋俊明, 他
    • Organizer
      日本内分泌学会
    • Place of Presentation
      神戸市
    • Year and Date
      2011-04-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate(IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals followed bymitogenic bioactivity of insulin-likegrowth factors(IGFs).2011

    • Author(s)
      福嶋俊明他
    • Organizer
      Gordon Research Conference : Insulin like growth factors inphysiology and disease.
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2011-03-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate (IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals followed by mitogenic bioactivity of insulin-like growth factors(IGFs)2011

    • Author(s)
      福嶋俊明, 他
    • Organizer
      Gordon Research Conference : Insul in like growth factors in physiology and disease
    • Place of Presentation
      Ventura, CA, USA
    • Year and Date
      2011-03-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate(IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals and mitogenicbioactivity of insulin-like growth factor(IGF).2010

    • Author(s)
      福嶋俊明他
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2011 Final Research Report
  • [Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate (IRS)-2 to membranefractions, enhancing IRS-2-mediated signals and mitogenic bioactivity of insulin-like growth factor(IGF).2010

    • Author(s)
      福嶋俊明, 他
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-10
    • Related Report
      2010 Annual Research Report
  • [Presentation] Insulinreceptor substrates(IRSs) interact with snoRNA.2010

    • Author(s)
      尾添敦史、福嶋俊明他
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Insulin receptor substrates (IRSs) interact with snoRNA.2010

    • Author(s)
      尾添敦史、福嶋俊明, 他
    • Organizer
      日本生化学会
    • Place of Presentation
      神戸
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Insulinreceptor substrates(IRSs) form a complexwith RNAs, affecting RNA metabolism andtranslation,2010

    • Author(s)
      尾添敦史、福嶋俊明他
    • Organizer
      International Congress ofthe GRS and the IGF Society
    • Place of Presentation
      New York, USA
    • Year and Date
      2010-10-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Insulin receptor substrates (IRSs) form a complex with RNAs, affecting RNA metabolism and translation2010

    • Author(s)
      尾添敦史、福嶋俊明, 他
    • Organizer
      International Congress of the GRS and the IGF Society
    • Place of Presentation
      New York, USA
    • Year and Date
      2010-10-06
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/ikagaku/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/ikagaku/

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://home.hiroshima-u.ac.jp/ikagaku/

    • Related Report
      2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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