Physiological roles of ARF1 mRNA interacting with insulin receptor substrates

• Project/Area Number: 22780249
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Applied animal science
• Research Institution: Hiroshima University (2011); The University of Tokyo (2010)
• Principal Investigator: TOSHIAKI Fukushima 広島大学, 大学院・医歯薬学総合研究科, 助教 (70543552)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 代謝 / 内分泌制御 / シグナル伝達 / 発現制御 / 核酸 / タンパク質 / 応用動物

Research Abstract

We have previously found that insulin receptor substrates(IRSs), mediators of insulin/ insulin-like growth factors(IGFs) signals, are associated with RNA. In this study, we investigated roles of the complexes. Results suggest that IRSs play multiple roles ; 1) they promote small nucleolar RNA(snoRNA) biogenesis, leading to enhanced ribosomal maturation/ activation, and 2) they regulate internal ribosome entry site(IRES)-mediated translation.

Research Products

• [Journal Article] Phosphatidylinositol 3-kinase binding protein, PITKAP/XB130 is required for cAMP-induced amplification of IGF mitogenic activity in FRTL-5 thyroid cells. (2012)
  • Author(s): Yamanaka D, Akama T, Fukushima T, Nedachi T, Kawasaki C, Chida K, Minami S, Suzuki K, Hakuno F, Takahashi S-I.
  • Journal Title: Mol Endocrinol Volume: 26 Issue: 6 Pages: 1043-1055
  • DOI: 10.1210/me.2011-1349
  • Peer Reviewed
• [Journal Article] Novel missense mutation in the IGF-I receptor L2 domain results in intrauterine and postnatal growth retardation (2012)
  • Author(s): Kawashima Y, Higaki K, Fukushima T, Hakuno F, Nagaishi JI, Hanaki K, Nanba E, Takahashi SI, Kanzaki S
  • Journal Title: Clin.Endocrinol. Volume: (in press) Issue: 2 Pages: 246-54
  • DOI: 10.1111/j.1365-2265.2012.04357.x
  • Peer Reviewed
• [Journal Article] Xanthine Oxidoreductase Is Involved in Macrophage Foam Cell Formation and atherosclerosis development (2012)
  • Author(s): Kushiyama A, Okubo H, Sakoda H, Kikuchi T, Fujishiro M, Sato H, Kushiyama S, Iwashita M, Nishimura F, Fukushima T, Nakatsu Y, Kamata H, Kawazu S, Higashi Y, Kurihara H, Asano T.
  • Journal Title: Arterioscler Thromb Vasc Biol Volume: 32 Issue: 2 Pages: 291-298
  • DOI: 10.1161/atvbaha.111.234559
  • Peer Reviewed
• [Journal Article] Valsartan, independently of AT1 receptor or PPARγ, suppresses LPS-induced macrophage activation and improves insulin resistance in cocultured adipocytes. (2012)
  • Author(s): Iwashita M, Sakoda H, Kushiyama A, Fujishiro M, Ohno H, Nakatsu Y, Fukushima T, Kumamoto S, Tsuchiya Y, Kikuchi T, Kurihara H, Akazawa H, Komuro I, Kamata H, Nishimura F, Asano T.
  • Journal Title: American Journal of Physiology - Endocrinology and Metabolism Volume: 302 Issue: 3 Pages: 286-296
  • DOI: 10.1152/ajpendo.00324.2011
  • Peer Reviewed
• [Journal Article] Phosphatidylinositol 3-Kinase Binding Protein, PI3KAP/XB130 is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells (2012)
  • Author(s): 山中大介, 福嶋俊明, 他
  • Journal Title: Endocrinology Volume: (印刷中)
  • Peer Reviewed
• [Journal Article] HSP90 interacting with IRS-2 is involved in cAMP-dependent potentiation of IGF-I signals in FRTL-5 cells (2011)
  • Author(s): Fukushima T, Okajima H, Yamanaka D, Ariga M, Nagata S, Ito A, Yoshida H, Asano T, Chida K
  • Journal Title: Mol.Cell Endocrinol. Volume: 344 Issue: 1-2 Pages: 81-90
  • DOI: 10.1016/j.mce.2011.06.029
  • Peer Reviewed
• [Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis (2011)
  • Author(s): Nakatsu Y, Sakoda H, Kushiyama A, Zhang J, Ono H, Fujishiro M, Kikuchi T, Fukushima T, Yoneda M, Ohno H, Horike N, Kanna M, Tsuchiya Y, Kamata H, Nishimura F, Isobe T, Ogihara T, Katagiri H, Oka Y, Takahashi SI, Kurihara H, Uchida T, Asano T
  • Journal Title: J Biol Chem Volume: 286 Issue: 23 Pages: 20812-20822
  • DOI: 10.1074/jbc.m110.206904
  • Peer Reviewed
• [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity (2011)
  • Author(s): Ohno H, Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Otani Y, Okubo H, Yoneda M, Fukushima T, Kamata H, Nishimura F, Kurihara H, Katagiri H, Oka Y, Asano T
  • Journal Title: Am J Physiol Cell Physiol Volume: 300(5) Issue: 5 Pages: 1047-54
  • DOI: 10.1152/ajpcell.00416.2010
  • Peer Reviewed
• [Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin/insulin-like growth factor-I receptor tyrosine kinases (2011)
  • Author(s): Fukushima T, Arai T, Ariga M, Okajima H, Ooi Y, Iijima Y, Sone M, Cho Y, Ando Y, Kasahara K, Ozoe A, Yoshihara H, Chida K, Okada S, Kopchick JJ, Hakuno F, Takahashi S-I
  • Journal Title: Biochem Biophys Res Commun. Volume: 404 Issue: 3 Pages: 767-773
  • DOI: 10.1016/j.bbrc.2010.12.045
  • Peer Reviewed
• [Journal Article] Peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 associates with IRS-1 and enhances insulin actions and adipogenesis (2011)
  • Author(s): 中津祐介、福嶋俊明, 他
  • Journal Title: The Journal of biological chemistry Volume: (In press)
  • Peer Reviewed
• [Journal Article] 4F2hc stabilizes GLUT1 protein and increases glucose transport activity. (2011)
  • Author(s): 大野晴也、福嶋俊明, 他
  • Journal Title: American Journal of Physiology-Cell Physiology Volume: (In press)
  • Peer Reviewed
• [Journal Article] Insulin receptor substrates form high-molecular-mass complexes that modulate their availability to insulin insulin-like growth factor-I receptor tyrosine kinases. (2011)
  • Author(s): 福嶋俊明, 他
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 404(3) Pages: 767-73
  • Peer Reviewed
• [Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing CRE transcriptional activity (2010)
  • Author(s): Nakatsu Y, Sakoda H, Kushiyama A, Ono H, Fujishiro M, Horike N, Yoneda M, Ohno H, Kamata H, Tahara H, Isobe T, Nishimura F, Katagiri H, Oka Y, Fukushima T, Takahashi SI, Kurihara H, Uchida T, Asano T.
  • Journal Title: J. Biol. Chem Volume: 285 Issue: 43 Pages: 33018-33027
  • DOI: 10.1074/jbc.m110.137836
  • Peer Reviewed
• [Journal Article] Paraquat-induced oxidative stressrepresses phosphatidyl inositol 3-kinaseactivities leading to impaired glucoseuptake in 3T3-L1 adipocytes (2010)
  • Author(s): 柴田倫宏、福嶋俊明(5番目)他12名
  • Journal Title: The Journalof biological chemistry Volume: 285 Issue: 27 Pages: 20915-25
  • DOI: 10.1074/jbc.m110.126482
  • Peer Reviewed
• [Journal Article] Pin1 associates with and induces translocation of CRTC2 to the cytosol, thereby suppressing cAMP-responsive element transcriptional activity. (2010)
  • Author(s): 中津祐介、福嶋俊明, 他
  • Journal Title: The Journal of biological chemistry Volume: 285(43) Pages: 33018-27
  • NAID: 120006471211
  • Peer Reviewed
• [Journal Article] Paraquat-induced oxidative stress represses phosphatidylinositol 3-kinase activities leading to impaired glucose uptake in 3T3-L1 adipocytes. (2010)
  • Author(s): 柴田倫宏、福嶋俊明, 他
  • Journal Title: The Journal of biological chemistry Volume: 285(27) Pages: 20915-25
  • Peer Reviewed
• [Presentation] Roles of peptidyl-prolyl cis/ trans isomerase NIMA-interacting 1 in non-alcoholicstea tohepatitis. (2011)
  • Author(s): 中津祐介福嶋俊明, 他
  • Organizer: 日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-24
• [Presentation] Roles of peptidyl-prolyl cis/trans isomerase NIMA-interacting 1 in non-alcoholic steatohepatitis (2011)
  • Author(s): 中津祐介, 福嶋俊明, 他
  • Organizer: 日本生化学会
  • Place of Presentation: 京都市
  • Year and Date: 2011-09-24
• [Presentation] Nedd4 potentiates insulin signals through ubiquitination of IRS-2 in hepatocytes. (2011)
  • Author(s): 福嶋俊明他
  • Organizer: 日本生化学会
  • Place of Presentation: 京都
  • Year and Date: 2011-09-23
• [Presentation] Nedd4 potentiates insulin signals through ubiquitination of IRS-2 in hepatocytes (2011)
  • Author(s): 福嶋俊明, 他
  • Organizer: 日本生化学会
  • Place of Presentation: 京都市
  • Year and Date: 2011-09-23
• [Presentation] Ubiquitination of insulin receptor substrate by Nedd4 potentiates insulin/ IGF signals. (2011)
  • Author(s): 福嶋俊明他
  • Organizer: 日本生化学会中国四国支部会
  • Place of Presentation: 広島
  • Year and Date: 2011-05-14
• [Presentation] Ubiquitination of insulin receptor substrate by Nedd4 potentiates insul in/IGF signals (2011)
  • Author(s): 福嶋俊明, 他
  • Organizer: 日本生化学会中国四国支部会
  • Place of Presentation: 広島市
  • Year and Date: 2011-05-14
• [Presentation] PGAM5, aserine/ threonine phosphatase associating with IRS, is required for the enhancement of insulin response. (2011)
  • Author(s): 鋳延淳一福嶋俊明他
  • Organizer: 日本内分泌学会
  • Place of Presentation: 神戸
  • Year and Date: 2011-04-22
• [Presentation] PGAM5, a serine/threonine phosphatase associating with IRS, is required for the enhancement of insulin response (2011)
  • Author(s): 鋳延淳一, 福嶋俊明, 他
  • Organizer: 日本内分泌学会
  • Place of Presentation: 神戸市
  • Year and Date: 2011-04-22
• [Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate(IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals followed bymitogenic bioactivity of insulin-likegrowth factors(IGFs). (2011)
  • Author(s): 福嶋俊明他
  • Organizer: Gordon Research Conference : Insulin like growth factors inphysiology and disease.
  • Place of Presentation: Ventura, CA, USA
  • Year and Date: 2011-03-01
• [Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate (IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals followed by mitogenic bioactivity of insulin-like growth factors(IGFs) (2011)
  • Author(s): 福嶋俊明, 他
  • Organizer: Gordon Research Conference : Insul in like growth factors in physiology and disease
  • Place of Presentation: Ventura, CA, USA
  • Year and Date: 2011-03-01
• [Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate(IRS)-2 to membrane fractions, enhancing IRS-2-mediated signals and mitogenicbioactivity of insulin-like growth factor(IGF). (2010)
  • Author(s): 福嶋俊明他
  • Organizer: 日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] Ubiquitin ligase Nedd4 recruits insulin receptor substrate (IRS)-2 to membranefractions, enhancing IRS-2-mediated signals and mitogenic bioactivity of insulin-like growth factor(IGF). (2010)
  • Author(s): 福嶋俊明, 他
  • Organizer: 日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-10
• [Presentation] Insulinreceptor substrates(IRSs) interact with snoRNA. (2010)
  • Author(s): 尾添敦史、福嶋俊明他
  • Organizer: 日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Insulin receptor substrates (IRSs) interact with snoRNA. (2010)
  • Author(s): 尾添敦史、福嶋俊明, 他
  • Organizer: 日本生化学会
  • Place of Presentation: 神戸
  • Year and Date: 2010-12-09
• [Presentation] Insulinreceptor substrates(IRSs) form a complexwith RNAs, affecting RNA metabolism andtranslation, (2010)
  • Author(s): 尾添敦史、福嶋俊明他
  • Organizer: International Congress ofthe GRS and the IGF Society
  • Place of Presentation: New York, USA
  • Year and Date: 2010-10-06
• [Presentation] Insulin receptor substrates (IRSs) form a complex with RNAs, affecting RNA metabolism and translation (2010)
  • Author(s): 尾添敦史、福嶋俊明, 他
  • Organizer: International Congress of the GRS and the IGF Society
  • Place of Presentation: New York, USA
  • Year and Date: 2010-10-06
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/ikagaku/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/ikagaku/
• [Remarks]
  • URL: http://home.hiroshima-u.ac.jp/ikagaku/