Multi-factorial analysis of stress reaction in the brain depending on cyclooxygenase-2
| Project/Area Number |
22780260
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Basic veterinary science/Basic zootechnical science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
MATSUWAKI Takashi 東京大学, 大学院・農学生命科学研究科, 特任助教 (20447361)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ストレス / 生理学 / 神経科学 |
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| Research Abstract |
We determined interleukin-1. as a regulator of cyclooxygenase-2 in the brain under stress conditions and found that stress response of neuroendocrine system is mediated by cyclooxygenase-2 in the brain under LPS and restraint stress conditions, but rather independent on it under hypoglycemic stress. In addition, we demonstrated that hypernutrition environment induced by sucrose consumption in the adolescence reduces the anxiety tendency after maturation.
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Report
(3 results)
Research Products
(6 results)
