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Multi-factorial analysis of stress reaction in the brain depending on cyclooxygenase-2

Research Project

Project/Area Number 22780260
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Basic veterinary science/Basic zootechnical science
Research InstitutionThe University of Tokyo

Principal Investigator

MATSUWAKI Takashi  東京大学, 大学院・農学生命科学研究科, 特任助教 (20447361)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsストレス / 生理学 / 神経科学
Research Abstract

We determined interleukin-1. as a regulator of cyclooxygenase-2 in the brain under stress conditions and found that stress response of neuroendocrine system is mediated by cyclooxygenase-2 in the brain under LPS and restraint stress conditions, but rather independent on it under hypoglycemic stress. In addition, we demonstrated that hypernutrition environment induced by sucrose consumption in the adolescence reduces the anxiety tendency after maturation.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (6 results)

All 2012 2011 2010

All Presentation (6 results)

  • [Presentation] Glucocorticoids differentially regulate cyclooxygenase-2-related signaling pathway in the hypothalamus under various stress conditions2012

    • Author(s)
      Yanbo Ma, Takashi Matsuwaki, Keitaro Yamanouchi, Masugi Nishihara
    • Organizer
      Society of Neuroscience
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of sucrose consumption in adolescence on anxiety behavior in adulthood in rats2011

    • Author(s)
      Takashi Matsuwaki, Yuka Iwahashi, Keitaro Yamanouchi, Masugi Nishihara
    • Organizer
      Society of Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] Effects of sucrose consumption in adolescence on anxiety behavior in adulthood in rats2011

    • Author(s)
      Takashi Matsuwaki
    • Organizer
      Neuroscience 2012, Society of Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Year and Date
      2011-11-13
    • Related Report
      2011 Annual Research Report
  • [Presentation] 若齢期栄養状態が成熟後の不安傾向、記憶能およびストレス耐性に与える影響2010

    • Author(s)
      岩橋佑佳、松脇貴志、山内啓太郎、西原真杉
    • Organizer
      第150回日本獣医学会学術集会
    • Place of Presentation
      北海道帯広市
    • Year and Date
      2010-09-16
    • Related Report
      2011 Final Research Report
  • [Presentation] 若齢期栄養状態が球熟後の不安傾向、記憶能およびストレス耐性に与える影響2010

    • Author(s)
      岩橋佑佳
    • Organizer
      第150回日本獣医学会学術集会
    • Place of Presentation
      北海道帯広市
    • Year and Date
      2010-09-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] 若齢期栄養状態が成熟後の脳機能に与える影響2010

    • Author(s)
      岩橋佑佳、松脇貴志、山内啓太郎、西原真杉
    • Organizer
      第10回行動神経内分泌研究会
    • Place of Presentation
      茨城県古河市
    • Year and Date
      2010-09-13
    • Related Report
      2011 Final Research Report 2010 Annual Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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