Characterisation and clinical analysis of SNP in obese cat
| Project/Area Number |
22780270
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Nippon Veterinary and Life Science University |
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Principal Investigator |
山本 一郎 日本獣医生命科学大学, 獣医学部, 講師 (00424763)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 疾病予防 / 制御 / SNP / CDKAL1 / ネコ / 肥満 / 糖尿病 / イヌ / Cdkal1 / ゲノム / cDNA / 遺伝子診断 / ゲノムDNA |
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| Research Abstract |
The lifestyle-related illnesses became popular in domestic animal, especially obese, increases the risk of type 2 diabetes in cat. The CDK5 regulatory subunit-associated protein 1-like 1 (Cdkal1) gene encodes methylthiotransferase, and the gene contains risk variants for type 2 diabetes in human. Genotyping analysis of single nucleotide polymorphism (SNP) for cat Cdkal1 revealed that obese cats have different tendency from normal cats. These findings suggest that cat Cdkal1 may be a candidate marker for genetic diagnosis of obesity.
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Report
(4 results)
Research Products
(48 results)
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[Journal Article] cDNA cloning and mRNA expression of cat and dog Cdkal1.2012
Author(s)
Yamamoto I, Ishikawa S, Li G, Takemitsu H, Fujiwara M, Mori N, Hatano H, Suzuki T, Mori A, Nakao N, Kawasumi K, Sako T, Aray T.
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Journal Title
Veterinary and Medicine: Research and Reports.
Volume: 3
Pages: 64-69
DOI
Related Report
Peer Reviewed
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