| Project/Area Number |
22780271
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Applied veterinary science
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| Research Institution | Azabu University |
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Principal Investigator |
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| Research Collaborator |
MAKI Takehiro 麻布大学, 大学院・獣医学研究科博士前期, 大学院生
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 脳由来神経栄養因子 / 神経細胞死 / 小脳顆粒細胞 / TrkB / メチル水銀 / 脳由来神経影響因子 |
|---|
| Research Abstract |
The mechanism of the accelerating effect of brain-derived neurotrophic factor(BDNF) on methylmercuryinduced neuronal death was investigated to elucidate in the present study. BDNF accelerated the MeHg-induced cell death and reduction of intracellular glutathione level(GSH), which was inhibited by U0126, a MEK inhibitor, among inhibitors against intracellular signal transduction pathways. While, another MEK inhibitor did not. These results indicate that the accelerating effect of BDNF on MeHg-induced neuronal death includes the reduction of GSH level and is contributed by factors that U0126 specifically acts on.
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