Clarification of unaccountable mechanisms in novel canine neutrophil dysfunction to find new treatment

• Project/Area Number: 22780277
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Clinical veterinary science
• Research Institution: Iwate University
• Principal Investigator: KOBAYASHI Saori 岩手大学, 農学部, 助教 (60566214)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 家族性好中球機能不全症 / β2-インテグリン / 犬 / ウシラクトフェリン / CD11b/CD18 / 好中球機能不全症 / インテグリン / 犬白血球粘着不全症 / 活性酸素産生

Research Abstract

We found a mixed-breed male dog with novel familial neutrophil dysfunction. The disorder was caused by a decrease of β2-integrin expression encoding CD18 without mutation, followed by a profound decrease of superoxide production. Our results indicate that oral treatment with bovine lactoferrin increases neutrophil β2-integrin transcript level, leading to the up regulation of neutrophil functions and improvement of clinical symptoms in the dog with familial neutrophil dysfunction.

Research Products

• [Journal Article] Clinical effects of bovine lactoferrin on two canine cases with familial neutrophil dysfunction (2012)
  • Author(s): Sato R, Kobayashi S, Abe Y, Kamishina H, Oda S, Yasuda J, Sasaki J.
  • Journal Title: The Journal of Veterinary Medical Science Volume: 74
  • NAID: 130001879759
  • Peer Reviewed
• [Journal Article] Clinical effects of bovine lactoferrin on two canine cases with familial neutrophil dysfunction (2012)
  • Author(s): Sato R, Kobayashi S, Abe Y, Kamishina H, Oda S, Yasuda J, Sasaki J
  • Journal Title: The Journal of Veterinary Medical Science Volume: 74(掲載確定)
  • NAID: 130001879759
  • Peer Reviewed
• [Journal Article] Oral administration of bovine lactoferrin upregulates neutrophil functions in a dog with familial β2-integrin-related neutrophil dysfunction (2011)
  • Author(s): Kobayashi S, Abe Y, Inanami O, Oda S, Yamauchi K, Hankanga C, Yasuda J, Sato R.
  • Journal Title: Veterinary Immunology and Immunopathology Volume: 143(1-2) Pages: 155-161
  • NAID: 120003368094
  • Peer Reviewed
• [Remarks]
  • URL: http://news7al.atm.iwate-u.ac.jp/~naika/works/naika2_study.html#koutyuukyuu
• [Remarks]
  • URL: http://news7al.atm.iwate-u.ac.jp/~naika/works/naika2_study.html#koutyuukyuu
• [Remarks]
  • URL: http://news7al.atm.iwate-u.ac.jp/cgi-bin/researcher_new/index.cgi?no=4