Clarification of unaccountable mechanisms in novel canine neutrophil dysfunction to find new treatment
| Project/Area Number |
22780277
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Iwate University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 家族性好中球機能不全症 / β2-インテグリン / 犬 / ウシラクトフェリン / CD11b/CD18 / 好中球機能不全症 / インテグリン / 犬白血球粘着不全症 / 活性酸素産生 |
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| Research Abstract |
We found a mixed-breed male dog with novel familial neutrophil dysfunction. The disorder was caused by a decrease of β2-integrin expression encoding CD18 without mutation, followed by a profound decrease of superoxide production. Our results indicate that oral treatment with bovine lactoferrin increases neutrophil β2-integrin transcript level, leading to the up regulation of neutrophil functions and improvement of clinical symptoms in the dog with familial neutrophil dysfunction.
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Report
(3 results)
Research Products
(6 results)
