Detection of a defense system of intestinal mucosa as a novel examination tool for canine inflammatory bowel disease
| Project/Area Number |
22780279
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Clinical veterinary science
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| Research Institution | Tokyo University of Agriculture and Technology |
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Principal Investigator |
IDE Kaori 東京農工大学, 大学院・農学研究院, 助教 (40550281)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 犬 / 炎症性腸疾患 / 腸管型アルカリフォスファターゼ / 腸管粘膜上皮 / 獣医内科学 / 腸炎 / IBD / 酵素 |
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| Research Abstract |
Intestinal alkaline phosphatase (iALP) was found to be expressed with enzymatic activity, more intensively in mucosal epithelia of duodenum than of colon, in dogs. Dephosphorylation reaction of lipopolysaccharide (LPS), which is the core function of the defense mechanism by iALP against excessive intestinal microflora, was also proven to be active. Fecal iALP concentration was shown to be high in cases of severe inflammatory bowel disease with high clinical activity score.
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Report
(4 results)
Research Products
(8 results)
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[Journal Article] Identification of a novel Staphylococcus pseudintermedius exfoliative toxin gene and its prevalence in isolates from canines with pyoderma and healthy dogs2010
Author(s)
Iyori, K., Hisatsune, J., Kawakami, T., Shibata, S., Murayama, N., Ide, K., Nagata, M., Fukata, T., Iwasaki, T., Oshima, K., Hattori, M., Sugai, M., Nishifuji, K.
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Journal Title
FEMS Microbiology Letters
Volume: 312
Pages: 169-175
Related Report
Peer Reviewed
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