Construction of Polycyclic Compounds via Rhodacycle Intermediate and Its Application to the Asymmetric S ynthesis
| Project/Area Number |
22790002
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Hokkaido University |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | ロジウム / アルキン / アレン / アルデヒド / NHC / 含窒素ヘテロ環カルベン / 環化反応 / ヒドロアシル化 / 環化二量化 |
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| Research Abstract |
Rh(I)-catalyzed intermolecular cycloaddition of 4-allenals with terminal alkynes proceeds smoothly, giving 6-membered cyclic compounds in good to high yields with high regioselectivities. It was also found that in the case of the chiral allene studied, chirality is almost conserved in the course of the cyclization. During ongoing investigation of this cycloaddition, we discovered another type of cyclization of allenynes with tethered aldehydes.
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Report
(3 results)
Research Products
(23 results)
