| Project/Area Number |
22790004
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kanagawa University of Human Services |
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Principal Investigator |
YASUI Yoshizumi 神奈川県立保健福祉大学, 保健福祉学部, 講師 (10432410)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 有機分子 / 超分子化学 / 自己組織化 / 光学分割 / 分離膜 / 有機化学 / 超分子 / 工学分割 |
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| Research Abstract |
In this project, we set up our goal to construct optically active molecular membranes through aggregation of cyclic helicene trimers. Such optically active membranes can be used for the separation of enantiomers : optically active samples will be available through simple membrane filtration. The molecular sheet will be fabricated through hydrogen-bonding network between cyclic helicene trimers having 2, 6-diamidopyridines on each m-phenylene parts, and diamides
Cyclic helicene trimers possessing one or three diamidopyridines were synthesized. Diiodobenzene derivative having Boc-protected 2, 6-diamidopyridine moiety was reacted with diethynyl helicene trimer by the Sonogashira condition. After cleavage of the Boc group, desired cyclic helicene trimer was obtained. Similarly, cyclic helicene trimer having three diamidopyridines was synthesized. The assembly of these cyclic compounds with diimides was studied by 1H NMR, CD, UV and AFM.
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