| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Research Abstract |
We have been working on the synthesis of functionalized amino acids and naturally occurring cyclodepsipeptides. As part of this research, we would develop an organocatalytic enantioselective synthesis of unusual amino acids. Homophimin A and lydiamycin A were selected as target compouds for this purpose. We have synthesized all constituents of homophimie A and the cyclic part of homophimine A. In the synthesis of lydiamycin A, piperazic acid was stereoselectively synthesized with proline catalyzed hydrazination. We have achieved the synthesis of the proposed structure of lydiamycin A.
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