Catalytic and Enantioselective Construction of Cyclohexane-fused Heterocycles
| Project/Area Number |
22790007
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | Chiba University |
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Principal Investigator |
HARADA Shinji 千葉大学, 大学院・薬学研究院, 助教 (10451759)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 不斉合成 / 合成化学 / 不斉触媒 / ヒドロカルバゾール / 多環性骨格構築 / 触媒的不斉反応 / Diels-Alder反応 / ツリウム / ランタノイド / ビスチオウレア型配位子 / カルバゾール / 伊藤-三枝酸化 |
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| Research Abstract |
The cycloaddition between siloxyvinyl-indole and dienophile gave hydrocarbazoles in up to quant. and 93% ee by using a novel chiral Thulium(III) catalyst. Synthetic application of adducts to biologically active compounds was also performed. It is noteworthy that this reaction system could be extendable to other heteroaromatic compounds.
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Report
(4 results)
Research Products
(23 results)
