Design and synthesis of dual activated bioprobe for proteins and DNAs

• Project/Area Number: 22790009
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Chemical pharmacy
• Research Institution: Kyoto University
• Principal Investigator: TAKASU Kiyosei 京都大学, 大学院・薬学研究科, 教授 (10302168)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
• Keywords: ケミカルバイオロジー / 有機合成化学 / 生体高分子 / 化学修飾 / DNA切断活性 / シクロブタン / pH応答 / DNA / アルキル化剤 / 標識プローブ / 低分子化合物 / 環境応答型分子 / シクロブタノール / 転位反応

Research Abstract

We have developed pH-responsible DNA cleaving agents using fused-cyclobutanols as precursors activated via ring contraction rearrangement. It is important for improvement of reactivity to design molecules stabilizing cation intermediates. In addition, we found that benzo-fused cyclobutanol showed DNA cleavage activity and this activity was stronger with higher concentration and more acidic pH condition. Further investigation about DNA alkylation mechanism and higher active compounds are ongoing in our laboratory.

Research Products

• [Journal Article] Acid-Catalyzed [2+2] Cycloaddition at Room-Temperature with Suppression of Side Reactions by Using a Flow Microreactor System (2012)
  • Author(s): Kurahashi, K.; Takemoto, Y.; Takasu, K.
  • Journal Title: ChemSusChem Volume: 5 Issue: 2 Pages: 270-273
  • DOI: 10.1002/cssc.201100373
  • Peer Reviewed
• [Journal Article] Facile Isomerization of Silyl Enol Ethers Catalyzed by Triflic Imide and Its Application to One-pot Isomerization→(2+2)Cycloaddition (2012)
  • Author(s): Inanaga, K.; Ogawa, Y.; Nagamoto, Y.; Daigaku, A.; Tokuyama, H.; Takemoto, Y.; Takasu, K.
  • Journal Title: Beilstein J.Org.Chem. Volume: (掲載確定)
  • Peer Reviewed
• [Journal Article] Formal (3+3) Cycloaddition of Silyl Enol Ethers Catalyzed by Trifric Imide: Domino Michael Addition-Claisen Condensation Accompanied with Isomerization of Silyl Enol Ethers (2011)
  • Author(s): Azuma, T.; Takemoto, Y.; Takasu, K.
  • Journal Title: Chemical and Pharmaceutical Bulletin Volume: 59 Issue: 9 Pages: 1190-1193
  • DOI: 10.1248/cpb.59.1190
  • NAID: 130001852326
  • ISSN: 0009-2363, 1347-5223
  • Peer Reviewed
• [Journal Article] Catalyst-Controlled Torquoselectivity Switch in the 4π Ring-Opening Reaction of 2-Amino-2-azetines Giving β-Substituted α,β-Unsaturated Amidines (2011)
  • Author(s): Shindoh, N.; Kitaura, K.; Takemoto, Y.; Takasu, K.
  • Journal Title: J.Am.Chem.Soc. Volume: 133 Issue: 22 Pages: 8470-8473
  • DOI: 10.1021/ja202576e
  • Peer Reviewed
• [Journal Article] Unprecedented Synthesis of N,N-Divinylamines by Tf2NH-Catalyzed Reaction of Ynamide with Ketimine (2011)
  • Author(s): Shindoh, N.; Takemoto, Y.; Takasu, K.
  • Journal Title: Heterocycles Volume: 82 Issue: 2 Pages: 1133-1136
  • DOI: 10.3987/com-10-s(e)87
  • NAID: 40018702702
  • Peer Reviewed
• [Journal Article] Gold (I)-Catalyzed Polycyclizations of Poly (enyne) anilines Based on Hydroamination and Consecutive Hydroarylation Cascade (2011)
  • Author(s): Hirano, K., Ohno, H., et al
  • Journal Title: J.Org.Chem. Volume: 76 Issue: 21 Pages: 9068-9080
  • DOI: 10.1021/jo2018119
  • Peer Reviewed
• [Journal Article] 軸性不斉をもつアミジンの触媒的不斉合成法の開発とキラル合成素子としての活用 (2011)
  • Author(s): 高須清誠
  • Journal Title: 薬学研究の進歩 Pages: 31-36
• [Journal Article] Unprecedented Synthesis of N, N-Divinylamines by Tf_2NH-Catalyzed Reaction of Ynamide with Ketimine (2011)
  • Author(s): Takasu, K.; N.Shindoh, Y.Takemoto
  • Journal Title: Heterocycles Volume: 82 Pages: 133-1136
  • Peer Reviewed
• [Journal Article] ynthesis and Properties of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by a 1, 5-Disubstituted Triazole (2010)
  • Author(s): Takasu, K.; Azuma, T.; Enkhtaivan, I.; Takemoto, Y.
  • Journal Title: Molecules Volume: 15 Pages: 8327-8348
• [Journal Article] Enantioselective Total Synthesis of(-)-and(+)-Petrosin (2010)
  • Author(s): Toya, H.; Okano, K.; Takasu, K.; Ihara, M.; Takahashi, A.; Tanaka H.; Tokuyama, H.
  • Journal Title: Org. Lett. Volume: 12 Issue: 22 Pages: 5196-5199
  • DOI: 10.1021/ol1022257
  • NAID: 110009757763
• [Journal Article] Auto-tandem Catalysis : Facile Synthesis of Substituted Alkylidenecyclohexanones by Domino(4+2) Cycloaddition-Elimination Reaction (2010)
  • Author(s): Reaction. K. Takasu, T. Tanaka, T. Azuma, Y. Takemoto
  • Journal Title: Chem. Commun Volume: 46 Issue: 43 Pages: 8246-8248
  • DOI: 10.1039/c0cc03336g
• [Journal Article] Stereocontrolled Synthesis of Spiro[n. 2] alkenes by Ring Contraction of Fused-Cyclobutanols (2010)
  • Author(s): K. Takasu, Y. Nagamoto, Y. Takemoto
  • Journal Title: Chem. Eur Volume: 16 Pages: 8427-8432
• [Journal Article] Synthesis of Trifunctional Thioureas Bearing 1, 5-Disubstituted Triazole Tether by Ru-Ctalayzed Huisgen Cycloaddition (2010)
  • Author(s): K. Takasu, T. Azuma, Y. Takemoto
  • Journal Title: Tetrahedron Lett Volume: 51 Issue: 20 Pages: 2737-2740
  • DOI: 10.1016/j.tetlet.2010.03.053
• [Journal Article] Synthesis and Properties of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by a 1,5-Disubstituted Triazole. (2010)
  • Author(s): Takasu, K.; Azuma, T.; Enkhtaivan, I.; Takemoto, Y.
  • Journal Title: Molecules Volume: 15 Pages: 8327-8348
  • Peer Reviewed
• [Journal Article] Catalytic Asymmetric Synthesis of Both Enantiomers of 4-Substituted 1,4-Dihydropyridines with the Use of Bifunctional Thiourea-Ammonium Salts Bearing Different Counter ions. (2010)
  • Author(s): Takasu, K.; Yoshida, K.; Inokuma, T.; Takemoto, Y.
  • Journal Title: Molecules Volume: 15 Pages: 8305-8326
  • Peer Reviewed
• [Journal Article] Enantioselective Total Synthesis of (-)- and (+)-Petrosin. (2010)
  • Author(s): Takasu, K., 他6名
  • Journal Title: Organic Letter Volume: 12 Pages: 5196-5199
  • NAID: 110009757763
  • Peer Reviewed
• [Journal Article] Auto-tandem Catalysis : Facile Synthesis of Substituted Alkylidenecyclohexanones by Domino (4+2) Cycloaddition-Elimination Reaction. (2010)
  • Author(s): K.Takasu, T.Tanaka, T.Azuma, Y.Takemoto
  • Journal Title: Chem.Commun Volume: 46 Pages: 8246-8248
  • Peer Reviewed
• [Journal Article] Stereocontrolled Synthesis of Spiro[n.2]alkenes by Ring Contraction of Fused-Cyclobutanols. (2010)
  • Author(s): K.Takasu, Y.Nagamoto, Y.Takemoto
  • Journal Title: Chem.Eur.J. Volume: 16 Pages: 8427-8432
  • Peer Reviewed
• [Journal Article] Selective Accumulation of Rhodacyanine in the Plasmodial Mitochondria is Related to the Growth Inhibition of Malaria Parasites. (2010)
  • Author(s): K.Takasu, 他8名
  • Journal Title: Chemical Science Volume: 1 Pages: 206-209
  • Peer Reviewed
• [Journal Article] Bronsted Acid-Thiourea Co-catalysis : Asymmetric Synthesis of Functionalized 1,4-Dihydropyridines from β-Enaminoesters and α,β-Unsaturated Aldehydes. (2010)
  • Author(s): K.Takasu, K.Yoshida, T.Inokuma, Y.Takemoto
  • Journal Title: Synlett Volume: 1 Pages: 1865-1869
  • Peer Reviewed
• [Journal Article] Synthesis of Trifunctional Thioureas Bearing 1,5-Disubstituted Triazole Tether by Ru-Ctalayzed Huisgen Cycloaddition.. (2010)
  • Author(s): K.Takasu, T.Azuma, Y.Takemoto
  • Journal Title: Tetrahedron Letter Volume: 51 Pages: 2737-2740
  • Peer Reviewed
• [Journal Article] Total Synthesis of (±)-Lepadiformine A via Radical Translocation/Cyclization Reaction. (2010)
  • Author(s): Takasu, K, 他5名
  • Journal Title: Synlett Volume: 1 Pages: 822-826
  • Peer Reviewed
• [Journal Article] Fluorinated Rhodacyanine (SJL-01) Possessing High Efficacy for Visceral Leishmaniasis (VL). (2010)
  • Author(s): Takasu, K, 他12名
  • Journal Title: J.Med.Chem Volume: 53 Pages: 368-373
  • Peer Reviewed
• [Presentation] 環縮小転位反応の応用;pH依存型新規DNAアルキル化剤の創製 (2012)
  • Author(s): 永本祐樹、竹本佳司、高須清誠
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-31
• [Presentation] 連続的8π-6π電子環状反応による多環性シクロブタノールの合成 (2012)
  • Author(s): 岸田明日美、永本祐樹、竹本佳司、山岡庸介、山田健一、高須清誠
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-30
• [Presentation] 配座固定されたD環側鎖2もつステロイド誘導体の立体制御合成 (2012)
  • Author(s): 畑健二、竹本佳司、高須清誠
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-30
• [Presentation] C2対称ジアルデヒドのベンゾイン縮合による光学活性シクリトール類の合成 (2012)
  • Author(s): 姜法雄、山岡庸介、高須清誠、山田健一
  • Organizer: 日本薬学会第132年会
  • Place of Presentation: 北海道大学(北海道)
  • Year and Date: 2012-03-30
• [Presentation] 小員環の反応性を利用した低pH応答DNA切断分子の設計と合成 (2012)
  • Author(s): 高須清誠
  • Organizer: 日本化学会第92春季年会「特別企画:有機合成化学を起点とするものづくり戦略」
  • Place of Presentation: 慶応大学(神奈川県)(招待講演)
  • Year and Date: 2012-03-24
• [Presentation] 反応開発から生体機能性分子への応用まで。 (2012)
  • Author(s): 高須清誠
  • Organizer: 京都府立大学生命分子化学科セミナー・鴨叡会セミナー
  • Place of Presentation: 京都府、京都府立大学
  • Year and Date: 2012-01-31
• [Presentation] シクロブタンの合成化学:反応開発から生体機能性分子への応用まで (2012)
  • Author(s): 高須清誠
  • Organizer: 京都府立大学生命分子化学科セミナー・鴨叡会セミナー
  • Place of Presentation: 京都府立大学(京都府)(招待講演)
  • Year and Date: 2012-01-31
• [Presentation] 環縮小転位反応を利用したpH依存型新規アルキル化剤の創製 (2011)
  • Author(s): 永本祐樹、竹本佳司、高須清誠
  • Organizer: 第31回有機合成若手セミナー
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2011-11-16
• [Presentation] [2+2]環化付加と環縮小転位を利用した立体分岐的ステロイドD環側鎖修飾法の開発 (2011)
  • Author(s): 畑健二、竹本佳司、高須清誠
  • Organizer: 第100回有機合成シンポジウム
  • Place of Presentation: 早稲田大学(東京都)
  • Year and Date: 2011-11-10
• [Presentation] Diastereoselectivity Switch in the EtAlCl2-catalyzed(2+2)Cycloaddition of Silyl Enol Ethers (2011)
  • Author(s): Kenji Hata, Yoshiji Takemoto, Kiyosei Takasu
  • Organizer: 7th International Symposium on Integrated Synthesis (ISIS-7)
  • Place of Presentation: 舞子ビラ(兵庫県)
  • Year and Date: 2011-10-15
• [Presentation] 不飽和アミジンの立体選択的合成 (2011)
  • Author(s): 高須清誠
  • Organizer: 平成23年度化学系学協会東北大会
  • Place of Presentation: 宮城県、東北大学
  • Year and Date: 2011-09-17
• [Presentation] 触媒制御での4π電子環状反応における回転選択性の逆転:不飽和アミジンの立体選択的合成 (2011)
  • Author(s): 高須清誠
  • Organizer: 平成23年度化学系学協会東北大会:有機化学コロキウム
  • Place of Presentation: 東北大学(宮城県)(招待講演)
  • Year and Date: 2011-09-17
• [Presentation] Waste-minimized Enol Silylation Catalyzed by A Triflimide-amine Co-catalyst (2011)
  • Author(s): Kiyosei Takasu
  • Organizer: The Second International Symposium on Process Chemistry
  • Place of Presentation: Kyoto
  • Year and Date: 2011-08-11
• [Presentation] 含水条件での連続反応を利用したpH依存型新規DNAアルキル化剤の設計 (2011)
  • Author(s): 永本祐樹、竹本佳司、高須清誠
  • Organizer: 第9回次世代を担う有機化学シンポジウム
  • Place of Presentation: 長井記念ホール(東京都)
  • Year and Date: 2011-05-28
• [Presentation] Stereocotrolled Synthesis of Spirocyclopropanes from Fused-cyclobutanols by Ring Contraction (2011)
  • Author(s): Yuuki Nagamoto, Kiyosei Takasu, Yoshiji Takemoto
  • Organizer: 5th ChemComm International Symposium
  • Place of Presentation: 京都大学(京都府)
  • Year and Date: 2011-05-16
• [Presentation] Development of low pH-induced DNA cleaving agents based on a ring contraction rearrangement (2011)
  • Author(s): Yuuki Nagamoto, Yoshiji Taketnoto, Kiyosei Takasu
  • Organizer: 8th AFMC International Medicinal Chemistry Symposium (AIMECS08)
  • Place of Presentation: 京王プラザホテル(東京都)
• [Presentation] 転位を伴う連続的置換反応と含水反応条件への適用 (2011)
  • Author(s): 永本祐樹、竹本佳司、高須清誠
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: ツインメッセ静岡(静岡)
• [Presentation] シリルエノールエーテルの再生を利用した形式的[3+3]環化付加とclovaneの合成研究 (2011)
  • Author(s): 高須清誠、東巧、竹本佳司
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: ツインメッセ静岡(静岡)
• [Presentation] 触媒制御での4π電子環状反応における回転選択性の逆転 (2011)
  • Author(s): 高須清誠、進藤直哉、北浦和夫、竹本佳司
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: ツインメッセ静岡(静岡)
• [Presentation] 触媒的連続反応による多置換キノリンの新規合成法 (2011)
  • Author(s): 高須清誠、黒田悠介、進藤直哉、竹本佳司
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: ツインメッセ静岡(静岡)
• [Presentation] (-)-および(+)-petrosinの全合成 (2011)
  • Author(s): 戸谷博希, 岡野健太郎, 高須清誠, 井原正隆, 高橋淳, 田中晴雄, 徳山英利
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: ツインメッセ静岡(静岡)
• [Presentation] 4p電子環状反応による2-アゼチンの開環における触媒制御による回転選択性の逆転 (2010)
  • Author(s): 進藤直哉、竹本佳司、高須清誠
  • Organizer: 第30回有機合成若手セミナー
  • Place of Presentation: 大阪大学(大阪)
  • Year and Date: 2010-11-10
• [Presentation] [2+2]環化付加反応を利用した立体選択的シクロブタン構築法の開発 (2010)
  • Author(s): 高須清誠、畑健二、竹本佳司
  • Organizer: 第60回日本薬学会近畿支部大会
  • Place of Presentation: 摂南大学(大阪)
  • Year and Date: 2010-10-30
• [Presentation] アリルシランを用いた触媒的シリルエノールエーテル化法の開発 (2010)
  • Author(s): 高須清誠、倉橋慧、竹本佳司
  • Organizer: 第60回日本薬学会近畿支部大会
  • Place of Presentation: 摂南大学(大阪)
  • Year and Date: 2010-10-30
• [Presentation] Penitrem Eの合成研究 (2010)
  • Author(s): 岡野健太郎, 大津隆則, 細川法彦, 高須清誠, 徳山英利
  • Organizer: 第3回有機触媒シンポジウム
  • Place of Presentation: 東北大学(仙台)
  • Year and Date: 2010-09-22
• [Presentation] Catalytic Synthesis of Silyl Enol Ethers by Bronsted Acid-Base Catalysis (2010)
  • Author(s): Kiyosei takasu
  • Organizer: 18th International Conference on Organic Synthesis
  • Place of Presentation: Bergen(Norway)
  • Year and Date: 2010-08-01
• [Presentation] Atropisomerism ofα,β-unsaturated amidines : Stereoselective synthesis by catalytic domino reaction and optical resolution (2010)
  • Author(s): Kiyosei Takasu
  • Organizer: 22nd International Symposium on Chirality
  • Place of Presentation: Sapporo
  • Year and Date: 2010-07-12
• [Presentation] Synthesis of Chiral Thioureas Bearing an Additional Function at a Remote Position Tethered by 1,5-Disubstituted Triazol (2010)
  • Author(s): Kiyosei Takasu, Takumi Azuma, Yoshiji Takemoto
  • Organizer: The 11th French-Japanese Symposium on Medicinal and Fine Chemistry
  • Place of Presentation: 京都ガーデンパレス(京都)
  • Year and Date: 2010-05-10
• [Presentation] Asymmetric Synthesis of 3,4- and 2,3,4-Substituted 1,4-Dihydropyridines by Using Co-Catalysts of Bronsted Acid and Aminothiourea (2010)
  • Author(s): Kohzo Yoshida, Tsubasa Inokuma, Kiyosei Takasu, Yoshiji Takemoto
  • Organizer: The 11th French-Japanese Symposium on Medicinal and Fine Chemistry
  • Place of Presentation: 京都ガーデンパレス(京都)
  • Year and Date: 2010-05-10
• [Presentation] 環縮小転位反応を契機とする新規DNAアルキル化試薬の設計 (2010)
  • Author(s): 高須清誠、永本祐樹、畑健二、竹本佳司
  • Organizer: 日本ケミカルバイオロジー学会第5回年会
  • Place of Presentation: 慶応義塾大学(横浜)
• [Presentation] Atropisomerism of α,β-unsaturated amidines : Stereoselective synthesis by catalytic cascade reaction and optical resolution (2010)
  • Author(s): Naoya Shindoh, Kiyosei Takasu, Yoshiji Takemoto
  • Organizer: 5th Seoul-Osaka-Kyoto Joint Symposium
  • Place of Presentation: 大阪大学(大阪)(招待講演)
• [Presentation] イルジン類の生合成機構をモチーフとした環縮小転位反応の開発 (2010)
  • Author(s): 高須清誠、永本祐樹、竹本佳司
  • Organizer: 第24回天然物化学談話会
  • Place of Presentation: 三谷温泉ホテル明山荘(蒲郡)
• [Presentation] Atropisomerism of α,β-unsaturated amidines : Stereoselective synthesis by catalytic domino reaction and optical resolution (2010)
  • Author(s): Kiyosei Takasu, Naoya Shindoh, Yoshiji Takemoto
  • Organizer: 22nd International Symposium on Chirality
  • Place of Presentation: 札幌コンベンションセンター(札幌)
• [Presentation] Catalytic Synthesis of Silyl Enol Ethers by Bronsted Acid-Base Catalysis (2010)
  • Author(s): Kiyosei Takasu, Kei Kurahashi, Yoshiji Takemoto
  • Organizer: 18th International Conference on Organic Synthesis
  • Place of Presentation: Grieghallen culture and convention cnter(ノルウェー)
• [Presentation] Stereoselective Synthesis and Optical Resolution of Axially Chiral a,b-Unsaturated Amidines (2010)
  • Author(s): Naoya Shindoh, Yoshiji Takemoto, Kiyosei Takasu
  • Organizer: 18th International Conference on Organic Synthesis
  • Place of Presentation: Grieghallen culture and convention cnter(ノルウェー)
• [Presentation] Total Synthesis of (-) and (+)-Petrosin (2010)
  • Author(s): Hiroki Toya, Kentaro Okano, Atsushi Takahashi, Haruo Tanaka, Kiyosei Takasu, Masataka Ihara, Hidetoshi Tokuyama
  • Organizer: Tohoku University Global COE Program Summer School
  • Place of Presentation: 東北大学(仙台)(招待講演)
• [Presentation] Synthetic Studies on (-)-Historionicotoxin (2010)
  • Author(s): Akihiro Daigaku, Kentaro Okano, Kiyosei Takasu, Hidetoshi Tokuyama
  • Organizer: Tohoku University Global COE Program Summer School
  • Place of Presentation: 東北大学(仙台)
• [Presentation] (-)および(+)-Petrosinの全合成 (2010)
  • Author(s): 岡野健太郎, 戸谷博希, 高橋淳, 田中晴雄, 高須清誠, 井原正隆, 徳山英利
  • Organizer: 第27回有機合成セミナー
  • Place of Presentation: シーサイドホテル舞子ビラ神戸(神戸)
• [Presentation] (-)および(+)-Petrosinの全合成 (2010)
  • Author(s): 戸谷博希, 岡野健太郎, 高橋淳, 田中晴雄, 高須清誠, 井原正隆, 徳山英利
  • Organizer: 第52回天然有機化合物討論会
  • Place of Presentation: グランシップ(静岡)
• [Presentation] (-)および(+)-Petrosinの全合成 (2010)
  • Author(s): 戸谷博希, 岡野健太郎, 高橋淳, 田中晴雄, 高須清誠, 井原正隆, 徳山英利
  • Organizer: 第40回複素環化学討論会
  • Place of Presentation: 東北大学(仙台)
• [Presentation] Halide-Free Silyl Enol Etherification Catalyzed by Bronsted Acid-Base Co-Catalyst (2010)
  • Author(s): Kiyosei Takasu, Kei Kurahashi, Yoshiji Takemoto
  • Organizer: The Sixth International Symposium on Integrated Synthesis
  • Place of Presentation: シーサイドホテル舞子ビラ神戸(神戸)
• [Presentation] 4p電子環状反応による2-アゼチンの開環における触媒制御による回転選択性の逆転 (2010)
  • Author(s): 進藤直哉、竹本佳司、高須清誠
  • Organizer: 第36回反応と合成の進歩シンポジウム
  • Place of Presentation: ウインク愛知(名古屋)
• [Presentation] ジャマイカカシア抽出物から分離されたβ-カルボリン誘導体の変異原性 (2010)
  • Author(s): 麻野間正晴、多田敦子、野口昭一郎、小野田絢、高橋和彦、高須清誠、杉本健士、徳山英利、山崎壮、河村葉子、寺田久屋
  • Organizer: 日本環境変異原学会 第39回大会
  • Place of Presentation: つくば国際会議場(つくば)
• [Presentation] イルジン類をモチーフとしたアルキル化剤の創製研究(II):スピロ型シクロプロパンの位置選択的開環反応 (2010)
  • Author(s): 永本祐樹、竹本佳司、高須清誠
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都テルサ(京都)
• [Presentation] 平衡を利用した多置換シクロブタンのジアステレオ選択的合成 (2010)
  • Author(s): 高須清誠、畑健二、竹本佳司
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: ツインメッセ静岡(静岡)
• [Book] Encyclopedia of Reagents for Organic Synthesis (2012)
  • Author(s): Kiyosei Takasu
  • Publisher: Wiley(印刷中)
• [Book] ナノバイオ技術と創薬研究 (2012)
  • Author(s): 高須清誠
  • Publisher: メディカルドゥ
• [Book] ナノバイオ技術と創薬研究 (2012)
  • Author(s): 高須清誠(共著)
  • Total Pages: 6
  • Publisher: メディカルドゥ
• [Remarks]
  • URL: http://www.pharm.kyoto-u.ac.jp/gousei/index.html
• [Remarks]
  • URL: http://www.pharm.kyoto-u.ac.jp/gousei/index.html
• [Patent(Industrial Property Rights)] シリルエノールエーテル類の製造法 (2011)
  • Inventor(s): 高須清誠、竹本佳司、倉橋慧
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Filing Date: 2011-03-02
  • Overseas
• [Patent(Industrial Property Rights)] シリルエノールエーテル類の製造法 (2011)
  • Inventor(s): 高須清誠, 他2名
  • Industrial Property Rights Holder: 京都大学
  • Filing Date: 2011-03-02
  • Overseas