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Development of high active artificial nanozymes for enantioselective reactions

Research Project

Project/Area Number 22790010
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionOsaka University

Principal Investigator

TAKIZAWA Shinobu  大阪大学, 産業科学研究所, 准教授 (50324851)

Co-Investigator(Renkei-kenkyūsha) SASAI Hiroaki  大阪大学, 産業科学研究所, 教授 (90205831)
Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2010: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywords不斉触媒 / ナノ粒子 / 光学活性 / 環境調和型プロセス / トリアゾール / ドミノ反応 / aza-MBH反応 / RC反応 / 固定化触媒 / 有機分子触媒 / アザ-MBH反応 / 高分子 / アザ-マイケル反応
Research Abstract

Towards the construction of artificial nanozymes for enantioselective reactions, new chiral catalysts for the aza-MBH and the RC reaction, and spiro bis(1, 2, 3-triazolium) salts as room temperature ionic liquids have been developed.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (42 results)

All 2012 2011 2010 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (25 results) Book (3 results) Remarks (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Enantioselective Synthesis of a-Alkylidene-y-Butyrolactones : Intramolecular Rauhut-Currior Reaction Promoted by Acid/Base Organocatalysts2012

    • Author(s)
      Takizawa, S. ; Nguyen, T. M.-N. ; Grossmann, A. ; Enders, D. ; Sasai H.
    • Journal Title

      Angewandte Chemie International Edition

      Volume: 51 Issue: 22 Pages: 5423-5426

    • DOI

      10.1002/anie.201201542

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective synthesis of α-alkylidene-γ-butyrolactones via an intramolecular Rauhut-Currier reaction promoted by acid-base organocatalysts2012

    • Author(s)
      滝澤忍、T.M.-N.Nguyen、A.Grossmann、D.Enders、笹井宏明
    • Journal Title

      Angew.Chem.Int.Ed.

      Volume: 51(掲載確定)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Spiro Bis (1,2,3-triazolium) Salts as Chiral Ionic Liquids2011

    • Author(s)
      Y.Yoshida, S.Takizawa, H.Sasai
    • Journal Title

      Tetrahedron Letters

      Volume: 52 Issue: 51 Pages: 6877-6879

    • DOI

      10.1016/j.tetlet.2011.09.152

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Bifunctional Spiro-Type Organocatalyst with High Enantiocontrol : Application to the Aza-Morita-Baylis-Hillman Reactions2011

    • Author(s)
      S.Takizawa, K.Kiriyama, K.Ieki, H.Sasai
    • Journal Title

      Chem.Commun.

      Volume: 47 Issue: 32 Pages: 9227-9229

    • DOI

      10.1039/c1cc12784e

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An enantioselective organocatalyzed aza-MBH domino process : application to the facile synthesis of tetrahydropyridines2011

    • Author(s)
      滝澤忍、井上直人、笹井宏明
    • Journal Title

      Tetrahedron Lett.

      Volume: Vol.52 Issue: 3 Pages: 377-380

    • DOI

      10.1016/j.tetlet.2010.11.045

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] An enantioselective organocatalyzed aza-MBH domino process : Application to the facile synthesis of tetrahydropyridines2011

    • Author(s)
      滝澤忍、井上直人、笹井宏明
    • Journal Title

      Tetrahedron Lett.

      Volume: 52巻 Pages: 377-380

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective synthesis of isoindolines : Organocatalyzed domino process based on the aza-Morita-Baylis-Hillman(aza-MBH) reaction2010

    • Author(s)
      滝澤忍、井上直人、平田修一、笹井宏明
    • Journal Title

      Angew. Chem. Int. Ed.

      Volume: Vol.49 Issue: 50 Pages: 9725-9729

    • DOI

      10.1002/anie.201004547

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Acid-base organocatalysts for aza-Morita-Baylis-Hillman reaction of nitroalkenes2010

    • Author(s)
      滝澤忍、堀井厚志、笹井宏明
    • Journal Title

      Tetrahedron : Asymmetry

      Volume: Vol.21 Issue: 8 Pages: 891-894

    • DOI

      10.1016/j.tetasy.2010.05.027

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective synthesis of isoindolines : Organocatalyzed domino process based on the aza-Morita-Baylis-Hillman (aza-MBH) reaction2010

    • Author(s)
      滝澤忍、井上直人、平田修一、笹井宏明
    • Journal Title

      Angew.Chem.Int.Ed.

      Volume: 49巻 Pages: 9725-9729

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acid-base organocatalysts for the aza-Morita-Baylis-Hillman reaction of Nitroalkenes2010

    • Author(s)
      滝澤忍、堀井厚志、笹井宏明
    • Journal Title

      Tetrahedron : Asymmetry

      Volume: 21巻 Pages: 891-894

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] Enantioselective C-C bond-forming reactions using vanadium(V) complexes2012

    • Author(s)
      滝澤忍、小寺純平、Doss Rajesh、片山智美、笹井宏明
    • Organizer
      243rd ACS National Meeting
    • Place of Presentation
      San Diego(USA)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Final Research Report
  • [Presentation] Enantioselective C-C bond-forming reactions using vanadium(V) complexes2012

    • Author(s)
      滝澤忍、小寺純平、D.Rajesh、片山智美、笹井宏明
    • Organizer
      243rd ACS National Meeting
    • Place of Presentation
      San Diego(アメリカ)
    • Year and Date
      2012-03-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Intramolecular enantioselective Rauhut-Currier reaction2012

    • Author(s)
      T.M.-N.Nguyen、滝澤忍、A.Grossmann、D.Enders、笹井宏明
    • Organizer
      Aachen-Osaka Mini-Symposium
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2012-03-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Catalytic enantioselective coupling of phenanthrols2012

    • Author(s)
      小寺純平、滝澤忍、笹井宏明
    • Organizer
      The 15th SANKEN International Symposium and The 10th SANKEN Nanotechnology Symposium
    • Place of Presentation
      大阪大学(大阪府)
    • Year and Date
      2012-01-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Organocatalyzed domino process based on the aza-Morita-Baylis-Hillman(aza-MBH) reaction2011

    • Author(s)
      滝澤忍、平田修一、井上直人、笹井宏明
    • Organizer
      ICCEOCA-6
    • Place of Presentation
      香港(中国)
    • Year and Date
      2011-12-12
    • Related Report
      2011 Final Research Report
  • [Presentation] Organocatalyzed domino process based on the aza-Morita-Baylis-Hillman (aza-MBH) reaction2011

    • Author(s)
      滝澤忍、平田修一、井上直人、笹井宏明
    • Organizer
      ICCEOCA-6
    • Place of Presentation
      香港(中国)
    • Year and Date
      2011-12-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] Organocatalyzed domino process based on the aza-Morita-Baylis-Hillman(aza-MBH) reaction2011

    • Author(s)
      平田修一、滝澤忍、井上直人、笹井宏明
    • Organizer
      The 1st Junior International Conference on Cutting-Edge Organic Chemistry in Asia
    • Place of Presentation
      廈門(中国)
    • Year and Date
      2011-12-09
    • Related Report
      2011 Final Research Report
  • [Presentation] Organocatalyzed domino process based on the aza-Morita-Baylis-Hillman (aza-MBH) reaction2011

    • Author(s)
      平田修一、滝澤忍、井上直人、笹井宏明
    • Organizer
      The 1st Junior International Conference on Cutting-Edge Organic Chemistry in Asia
    • Place of Presentation
      廈門(中国)
    • Year and Date
      2011-12-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Organocatalyzed domino process based on the aza-Morita-Baylis-Hillman (aza-MBH) reaction2011

    • Author(s)
      滝澤忍、井上直人、平田修一、笹井宏明
    • Organizer
      International Symposium on Integrated Synthesis
    • Place of Presentation
      ビラ舞子(兵庫県)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Intramolecular enantioselective Rauhut-Currier reaction2011

    • Author(s)
      T.M.-N.Nguyen、滝澤忍、笹井宏明
    • Organizer
      International Symposium on Integrated Synthesis
    • Place of Presentation
      ビラ舞子(兵庫県)
    • Year and Date
      2011-11-09
    • Related Report
      2011 Annual Research Report
  • [Presentation] Enantioselective carbon-carbon bond-forming reactions using vanadium(V) complexes2011

    • Author(s)
      滝澤忍、小寺純平、Doss Rajesh、片山智美、笹井宏明
    • Organizer
      Aachen-Osaka Mini-Symposium
    • Place of Presentation
      Aachen(Germany)
    • Year and Date
      2011-09-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Enantioselective carbon-carbon bond-forming reactions using vanadium (V) complexes2011

    • Author(s)
      滝澤忍、小寺純平、D.Rajesh、片山智美、笹井宏明
    • Organizer
      Aachen-Osaka Mini-Symposium
    • Place of Presentation
      アーヘン工科大学(ドイツ)
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of new method for an efficient synthesis of spiro bis (triazole) derivatives and their applications to asymmetric catalysis2011

    • Author(s)
      吉田泰志、滝澤忍、笹井宏明
    • Organizer
      The 2^<nd> International Symposium on Process Chemistry
    • Place of Presentation
      国立京都国際会館(京都府)
    • Year and Date
      2011-08-10
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of bifunctional organocatalysts for enantioselective Morita-Baylis-Hillman reaction2010

    • Author(s)
      村上真耶、滝澤忍、笹井宏明
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hawaii(USA)
    • Year and Date
      2010-12-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Enantioselective aza-Morita-Baylis-Hillman(aza-MBH) domino reactions promoted by acid-base organocatalyst2010

    • Author(s)
      井上直人、滝澤忍、笹井宏明
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hawaii(USA)
    • Year and Date
      2010-12-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Bifunctional organocatalyst bearing(S)-1, 1'-spirobiindane as chiral backbone2010

    • Author(s)
      桐山貴美子、滝澤忍、笹井宏明
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hawaii(USA)
    • Year and Date
      2010-12-17
    • Related Report
      2011 Final Research Report
  • [Presentation] Bifunctional organocatalyst : bearing(S)-1,1'-spirobiindane as chiral backbone2010

    • Author(s)
      桐山貴美子、滝澤忍、笹井宏明
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hawaii Convention Center (USA)
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of bifunctional organocatalysts for enantioselective Morita-Baylis-Hillman reaction2010

    • Author(s)
      村上真耶、滝澤忍、笹井宏明
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hawaii Convention Center (USA)
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enantioselective aza-Morita-Baylis-Hillman (aza-MBH) domino reactions promoted by acid-base organocatalyst2010

    • Author(s)
      井上直人、滝澤忍、笹井宏明
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hawaii Convention Center (USA)
    • Year and Date
      2010-12-17
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enantioselective oxidative coupling of 2-naphthols using dinuclear vanadium complex2010

    • Author(s)
      滝澤忍、片山智美、Doss Rajesh、笹井宏明
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hawaii(USA)
    • Year and Date
      2010-12-16
    • Related Report
      2011 Final Research Report
  • [Presentation] Enantioselective oxidative coupling of 2-naphthols using dinaclear vanadium complex2010

    • Author(s)
      滝澤忍、片山智美、Doss Rajesh、笹井宏明
    • Organizer
      Pacifichem2010
    • Place of Presentation
      Hilton Hawaiian Village (USA)
    • Year and Date
      2010-12-16
    • Related Report
      2010 Annual Research Report
  • [Presentation] Morita-Baylis-Hillman(MBH)反応を基盤とする新規エナンチオ選択的炭素-炭素結合生成反応の開発2010

    • Author(s)
      滝澤忍、ウィンツエミンナト、堀井厚志、笹井宏明
    • Organizer
      第36回反応と合成の進歩シンポジウム
    • Place of Presentation
      ウインクあいち
    • Year and Date
      2010-11-02
    • Related Report
      2010 Annual Research Report
  • [Presentation] スピロキラリティーを有する酸-塩基型有機分子触媒の開発2010

    • Author(s)
      桐山貴美子、滝澤忍、笹井宏明
    • Organizer
      第36回反応と合成の進歩シンポジウム
    • Place of Presentation
      ウインクあいち
    • Year and Date
      2010-11-01
    • Related Report
      2010 Annual Research Report
  • [Presentation] 二核バナジウム触媒による2-ナフトール類の不斉酸化カップリング反応2010

    • Author(s)
      滝澤忍、Doss Rajesh、片山智美、小寺純平、笹井宏明
    • Organizer
      日本プロセス化学会2010サマーシンポジウム
    • Place of Presentation
      タワーホール船堀
    • Year and Date
      2010-07-15
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enantioselective domino reactions promoted by acid-base organocatalysts2010

    • Author(s)
      滝澤忍、井上直人、平田修一、笹井宏明
    • Organizer
      22nd International Symposium on Chirality
    • Place of Presentation
      札幌コンベンションセンター
    • Year and Date
      2010-07-14
    • Related Report
      2010 Annual Research Report
  • [Book] Comprehensive Chirality2012

    • Author(s)
      笹井宏明、滝澤忍
    • Publisher
      Elsevier(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] Polymeric Chiral Catalyst Design and Chiral Polymer Synthesis, Chapter 10 : Immobilization of Multicomponent Asymmetric Catalysts(MACs)2011

    • Author(s)
      笹井宏明、滝澤忍
    • Publisher
      John Wiley & Sons, Inc.
    • Related Report
      2011 Final Research Report
  • [Book] 触媒 特集「有機分子触媒による精密有機合成」2010

    • Author(s)
      笹井宏明、滝澤忍
    • Publisher
      触媒学会
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/soc/socmain.html

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/soc/socmain.html

    • Related Report
      2011 Annual Research Report
  • [Remarks]

    • URL

      http://www.sanken.osaka-u.ac.jp/labs/soc/socmain.html

    • Related Report
      2010 Annual Research Report
  • [Patent(Industrial Property Rights)] 光学活性スピロビストリアゾール誘導体の開発と応用2011

    • Inventor(s)
      笹井宏明、滝澤忍、吉田泰志
    • Industrial Property Rights Holder
      大阪大学
    • Industrial Property Number
      2011-053422
    • Filing Date
      2011-03-10
    • Related Report
      2011 Final Research Report

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Published: 2010-08-23   Modified: 2016-04-21  

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