| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
With the aim of developing a method that allows the generation of nucleophilic carbenes at a cryogenic temperature, we focused on an iminium salt derived from β-silyl-α,β-epoxyaldehydes, which can potentially generate a nucleophilic carbene via deprotonation of a proton on an iminium carbon atom, ring-opening of epoxide and Brook rearrangement of the resulting α-silyl alkoxide. We devised a method for the preparation of the substrates and found that some structural modification of the substrates is required to successfully generate a nucleophilc carbene. During the attempt, we also found that 1,n-dipole (n ≠3), a new class of synthons, can serve important intermediates in the synthesis of complex molecules.
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