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Development of a recapturable linker that enables isolation and labeling of target proteins

Research Project

Project/Area Number 22790012
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionThe University of Tokushima

Principal Investigator

SHIGENAGA Akira  徳島大学, 大学院・ヘルスバイオサイエンス研究部, 助教 (10423394)

Project Period (FY) 2010 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywordsアビジン / 蛋白質精製 / 蛋白質ラベル化 / ビオチン / プルダウン / ペプチド / ペプチド結合切断 / 有機合成化学
Research Abstract

In the field of proteomics, methodology of isolation followed by selective labeling of target proteins is indispensable. Therefore, we decided to develop a" Recapturable Linker" that enables isolation and selective labeling of the target proteins. As a result, the" Recapturable Linker" was synthesized and it was successfully applied to selective labeling of a model peptide of the target protein.

Report

(3 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2010 Annual Research Report
  • Research Products

    (101 results)

All 2012 2011 2010 Other

All Journal Article (37 results) (of which Peer Reviewed: 37 results) Presentation (58 results) Book (4 results) Remarks (2 results)

  • [Journal Article] Fmoc-based solid phase synthesis of adenylylated peptides using diester-type adenylylated amino acid derivatives2012

    • Author(s)
      Ogura, K.; Shigenaga, A.; Ebisuno, K.; Hirakawa, H.; Otaka, A
    • Journal Title

      Tetrahedron Lett

      Volume: (in press) Issue: 27 Pages: 3429-3432

    • DOI

      10.1016/j.tetlet.2012.04.063

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of a reduction-responsive amino acid that induces peptide bond cleavage in hypoxic cells2012

    • Author(s)
      Shigenaga, A., et al.
    • Journal Title

      ChemBioChem

      Volume: 13 Issue: 7 Pages: 968-971

    • DOI

      10.1002/cbic.201200141

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acyl transfer2012

    • Author(s)
      Shigenaga, A.; Hirakawa, H.; Yamamoto, J.; Ogura, K.; Denda, M.; Yamaguchi, K.; Otaka, A.
    • Journal Title

      Peptide Science 2011

      Pages: 385-386

    • NAID

      10030204614

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Double-kinetically controlled proline ligation2012

    • Author(s)
      Ding, H.; Sato, K.; Morishita, K.; Shigenaga, A.; Otaka, A.
    • Journal Title

      Peptide Science 2011

      Pages: 133-134

    • NAID

      10030204136

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-Sulfanylethylanilide peptide : a peptide thioester equivalent which can directly participate in native chemical ligation2012

    • Author(s)
      Sato, K.; Tsuda, S.; Sakamoto, K.; Shigenaga, A.; Otaka, A.
    • Journal Title

      Peptide Science 2011

      Pages: 13-14

    • NAID

      10030203930

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acyl transfer2012

    • Author(s)
      Shigenaga, A
    • Journal Title

      Peptide Science 2011

      Pages: 385-386

    • NAID

      10030204614

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Doubly-kinetically controlled proline ligation2012

    • Author(s)
      Ding, H.
    • Journal Title

      Peptide Science 2011

      Pages: 133-134

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-sulfanylethylanilide peptide : a peptide thioester equivalent wnicn can directly participate in native chemical ligation2012

    • Author(s)
      Sato, K.
    • Journal Title

      Peptide Science 2011

      Pages: 13-14

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of UV-responsive catch-and-release system of a cysteine protease model peptide2011

    • Author(s)
      Shigenaga, A.; Morishita, K.; Yamaguchi, K.; Ding, H.; Ebisuno, K.; Sato, K.; Yamamoto, J.; Akaji, K.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 67 Issue: 46 Pages: 8879-8886

    • DOI

      10.1016/j.tet.2011.09.062

    • NAID

      120006493356

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Design and synthesis of caged ceramide : UV-responsive ceramide releasing system based on UV-induced amide bond cleavage followed by O-N acyl transfer2011

    • Author(s)
      Shigenaga, A.; Hirakawa, H.; Yamamoto, J.; Ogura, K.; Denda, M.; Yamaguchi, K.; Tsuji, D.; Itoh, K.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 67 Issue: 22 Pages: 3984-3990

    • DOI

      10.1016/j.tet.2011.04.048

    • NAID

      120006493357

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual kinetically-controlled native chemical ligation using a combi-nation of sulfanylproline and sulfanyl-ethylanilide peptide2011

    • Author(s)
      Ding, H.; Shigenaga, A.; Sato, K.; Morishita, K.; Otaka, A
    • Journal Title

      Org. Lett

      Volume: 13 Issue: 20 Pages: 5588-5591

    • DOI

      10.1021/ol202316v

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-Sulfanylethylanilide peptide as a crypto-thioester peptide2011

    • Author(s)
      Sato, K.; Shigenaga, A.; Tsuji, K.; Tsuda, S.; Sumikawa, Y.; Sakamoto, K.; Otaka, A
    • Journal Title

      ChemBioChem

      Volume: 12 Issue: 12 Pages: 1840-1844

    • DOI

      10.1002/cbic.201100241

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Application of N-C-or C-N-directed sequential native chemical ligation to the preparation of CXCL14 analogs and their biological evaluation2011

    • Author(s)
      Tsuji, K.; Shigenaga, A.; Sumikawa, Y.; Tanegashima, K.; Sato, K.; Aihara, K.; Hara, T.; Otaka, A
    • Journal Title

      Bioorg. Med. Chem

      Volume: 19 Issue: 13 Pages: 4014-4020

    • DOI

      10.1016/j.bmc.2011.05.018

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] N-Sulfanylethylanilide derivative as a peptide thioester equivalent2011

    • Author(s)
      Sato, K.; Tsuda, S.; Tsuji, K.; Sakamoto, K.; Shigenaga, A.; Otaka, A.
    • Journal Title

      Proceedings of the Twenty-Second American Peptide Symposium

      Pages: 72-73

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol2011

    • Author(s)
      Tsuji, K.; Sumikawa, Y.; Tanegashima, K.; Shigenaga, A.; Hara, T.; Otaka, A.
    • Journal Title

      Proceedings of the Twenty-Second American Peptide Symposium

      Pages: 74-75

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of amide bond cleavage device with application to chemical biology use2011

    • Author(s)
      Otaka, A.; Shigenaga, A.
    • Journal Title

      Peptide Science 2010

      Volume: 49

    • NAID

      10028237182

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological evaluation of CXCL14 and its derivatives2011

    • Author(s)
      Tsuji, K.; Sumikawa, Y.; Tanegashima, K.; Shigenaga, A.; Hara, T.; Otaka, A.
    • Journal Title

      Peptide Science 2010

      Volume: 182

    • NAID

      10028237759

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective synthesis of stimulus-responsive amino acid via pyrrolidinyl tetrazole catalyzed asymmetricα-amination of aldehyde2011

    • Author(s)
      Shigenaga, A.; Yamamoto, J.; Nishioka, N.; Denda, M.; Otaka, A.
    • Journal Title

      Peptide Science 2010

      Volume: 202

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Native chemical ligation using N-peptidyl anilide as crypto-thioester2011

    • Author(s)
      Sato, K.; Tsuda, S.; Maeda, N.; Denda, M.; Shigenaga, A.; Otaka, A.
    • Journal Title

      Peptide Science 2010

      Volume: 203

    • NAID

      10028237853

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of nonhydrolyzable AMPylated amino acid analogues for uncovering the physiological role of AMPylation2011

    • Author(s)
      Ogura, K.; Hirakawa, H.; Shigenaga, A.; Otaka, A.
    • Journal Title

      Peptide Science 2010

      Volume: 205

    • NAID

      10028237863

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of recapturable cleavable linker for efficient enrichment and specific labeling of target proteins2011

    • Author(s)
      Yamamoto, J.; Maeda, N.; Denda, M.; Shigenaga, A.; Otaka, A.
    • Journal Title

      Peptide Science 2010

      Volume: 232

    • NAID

      10028237977

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Development of stimulus responsive thiol releasing system for controlling activity of cysteine protease2011

    • Author(s)
      Morishita, K.; Yamaguchi, K.; Ding, H.; Shigenaga, A.; Akaji, K.; Otaka, A.
    • Journal Title

      Peptide Science 2010

      Volume: 290

    • NAID

      10028238228

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dual kinetically-controlled native chemical ligation using a combination of sulfanylproline and sulfanylethylanilide peptide2011

    • Author(s)
      Ding, H
    • Journal Title

      Org.Lett.

      Volume: 13 Pages: 5588-5591

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N-sulfanylethylanilide peptide : a peptide thioester equivalent which can directly participate in native chemical ligation2011

    • Author(s)
      Sato, K.
    • Journal Title

      Proceedings of the Twenty-Second American Peptide Symposium

      Pages: 72-73

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of CXCL14 and its derivatives utilizing C to N or N to C directive sequential NCL protocol2011

    • Author(s)
      Tsuji, K.
    • Journal Title

      Proceedings of the Twenty-Second American Peptide Symposium

      Pages: 74-75

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of amide bond cleavage device with application to chemical biology use2011

    • Author(s)
      Otaka, A.
    • Journal Title

      Peptide Science 2010

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective synthesis of stimulus-responsive amino acid via pyrrolidinyl tetrazole catalyzed asymmetric α-amination of aldehyde2011

    • Author(s)
      Shigenaga, A.
    • Journal Title

      Peptide Science 2010

      Volume: (in press)

    • NAID

      10028237844

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Stimulus Responsive Thiol Releasing System for Controlling Activity of Cysteine Protease2011

    • Author(s)
      Morishita, K.
    • Journal Title

      Peptide Science 2010

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Recapturable Cleavable Linker for Efficient Enrichment and Specific Labeling of Target Proteins2011

    • Author(s)
      Yamamoto, J.
    • Journal Title

      Peptide Science 2010

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of nonhydrolyzable AMPylated amino acid analogues for uncovering the physiological role of AMPylation2011

    • Author(s)
      Ogura, K.
    • Journal Title

      Peptide Science 2010

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Native chemical ligation using N-peptidyl anilide as crypto-thioester2011

    • Author(s)
      Sato, K.
    • Journal Title

      Peptide Science 2010

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological evaluation of CXCL14 and its derivatives2011

    • Author(s)
      Tsuji, K.
    • Journal Title

      Peptide Science 2010

      Volume: (in press)

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective synthesis of stimulus-responsive amino acid via asymmetricα-amination of aldehyde2010

    • Author(s)
      Shigenaga, A.; Yamamoto, J.; Nishioka, N.; Otaka, A
    • Journal Title

      Tetrahedron

      Volume: 66 Issue: 37 Pages: 7367-7372

    • DOI

      10.1016/j.tet.2010.07.033

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Enantioselective synthesis of stimulus-responsive amino acid via asymmetric α-amination of aldehyde2010

    • Author(s)
      Shigenaga, A.
    • Journal Title

      Tetrahedron

      Volume: 66 Pages: 7367-7372

    • NAID

      120006493355

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A structure-activity relationship study elucidating the mechanism of sequence-specific collagen recognition by the chaperone HSP472010

    • Author(s)
      Nishikawa, Y.
    • Journal Title

      Bioorg.Med.Chem.

      Volume: 18 Pages: 3767-3775

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ペプチドチオエステル合成法の最近の進展2010

    • Author(s)
      重永章
    • Journal Title

      有機合成化学協会誌

      Volume: 68 Pages: 911-919

    • NAID

      10026870593

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 十字路:セーフティーキャッチリンカー2010

    • Author(s)
      重永章
    • Journal Title

      有機合成化学協会誌

      Volume: 68 Pages: 973-973

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Presentation] フッ化物イオン応答型アミノ酸の開発と標的タンパク質精製ツールへの応用2012

    • Author(s)
      山本純
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 4-チオプロリンを用いたNative Chemical Ligation法の開発2012

    • Author(s)
      丁昊
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] リン酸化タンパク質の機能解明に向けたケージド非水解性リン酸化アミノ酸含有ペプチドの合成研究2012

    • Author(s)
      傳田将也
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] CXCL14・CXCL12デュアルアンタゴニストペプチドの創製2012

    • Author(s)
      粟飯原圭佑
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新規チオール応答型アミノ酸の合成とDNA放出システムへの展開2012

    • Author(s)
      戎野紘司
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] タンパク質化学合成を指向したN-アミノアシルN-置換アニリンリンリンカーの効率的合成法の開発2012

    • Author(s)
      坂本一健
    • Organizer
      日本薬学会第132回年会
    • Place of Presentation
      北海道大学(札幌市)
    • Year and Date
      2012-03-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] Native chemical ligation (NCL) without using peptide thioester2011

    • Author(s)
      佐藤浩平
    • Organizer
      14th Peptide Forum
    • Place of Presentation
      鹿児島大学(鹿児島市)(招待講演)
    • Year and Date
      2011-12-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Application of Stimulus-responsive Amino Acid to Traceable Linker for Efficient Enrichment and Specific Labeling of Target Proteins2011

    • Author(s)
      山本純
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] The First Accomplishment of Development of CXCL14 Antagonistic Peptide by Dimerization of CXCL14 Fragment2011

    • Author(s)
      辻耕平
    • Organizer
      8th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      京王プラザホテル(東京都)
    • Year and Date
      2011-11-29
    • Related Report
      2011 Annual Research Report
  • [Presentation] 刺激応答型アミノ酸の開発とケミカルバイオロジー分野への展開2011

    • Author(s)
      重永章
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      高松
    • Year and Date
      2011-11-13
    • Related Report
      2011 Final Research Report
  • [Presentation] 刺激応答型アミノ酸の開発とケミカルバイオロジー分野への展開2011

    • Author(s)
      重永章
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンポートホール高松(高松市)(招待講演)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] AMP化タンパク質の機能解明を指向したペプチド性分子ツールの開発2011

    • Author(s)
      小倉圭司
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] CXCL14およびその誘導体の効率的合成法の開発と活性評価2011

    • Author(s)
      辻耕平
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] リン酸化タンパク質の機能解明に同けた紫外線応答型リン酸化アミノ酸誘導体の合成研究2011

    • Author(s)
      傳田将也
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] ペプチドチオエステル合成用アニリン型補助基への効率的アミノ酸導入法の開発2011

    • Author(s)
      坂本健
    • Organizer
      第50回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      サンポートホール高松(高松市)
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] タンパク質AMP化の生理学的意義解明を指向した新規分子ツールの開発2011

    • Author(s)
      小倉圭司
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      あわぎんホール(徳島市)
    • Year and Date
      2011-11-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] 4-メルカプトプロリンを用いたペプチドフラグメント縮合法の開発2011

    • Author(s)
      丁昊
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      あわぎんホール(徳島市)
    • Year and Date
      2011-11-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] タンパク質化学合成を指向したワンポット4成分連続縮合法の開発2011

    • Author(s)
      佐藤浩平
    • Organizer
      第37回反応と合成の進歩シンポジウム
    • Place of Presentation
      あわぎんホール(徳島市)
    • Year and Date
      2011-11-07
    • Related Report
      2011 Annual Research Report
  • [Presentation] N-Sulfanylethylanilide peptide : a peptide thioester equivalent which can directly participate in native chemical ligation2011

    • Author(s)
      佐藤浩平
    • Organizer
      第48回ペプチド討論会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-09-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Caged ceramide which releases parent ceramide after UV-induced amide bond cleavage followed by intramolecular O-N acy1 transfer2011

    • Author(s)
      重永章
    • Organizer
      第48回ペプチド討論会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-09-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Double-kinetically controlled proline ligation2011

    • Author(s)
      丁昊
    • Organizer
      第48回ペプチド討論会
    • Place of Presentation
      札幌コンベンションセンター(札幌市)
    • Year and Date
      2011-09-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Development of nucleocytoplasmic shuttle peptide using stimulus-responsive processing device2011

    • Author(s)
      大高章
    • Organizer
      日本生物物理学会第49回年会
    • Place of Presentation
      兵庫県立大学(姫路市)(招待講演)
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] タンパク質AMP化の生理学的意義解明に向けたAMP化アミノ酸誘導体の創製2011

    • Author(s)
      小倉圭司
    • Organizer
      創薬懇話会2011
    • Place of Presentation
      ダイヤモンド瀬戸内マリンホテル(岡山市)
    • Year and Date
      2011-07-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] 簡便かつ効率的タンパク質化学合成法の開発2011

    • Author(s)
      佐藤浩平
    • Organizer
      創薬懇話会2011
    • Place of Presentation
      ダイヤモンド瀬戸内マリンホテル(岡山市)
    • Year and Date
      2011-07-06
    • Related Report
      2011 Annual Research Report
  • [Presentation] Design and synthesis of traceable linker for efficient enrichment and specific labeling of target proteins2011

    • Author(s)
      山本純
    • Organizer
      22nd American Peptide Symposium
    • Place of Presentation
      Sheraton hotel (San Diego)
    • Year and Date
      2011-06-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] N-sulfanylethylanilide derivative as a peptide thioester equivalent2011

    • Author(s)
      佐藤浩平
    • Organizer
      22nd American Peptide Symposium
    • Place of Presentation
      Sheraton hotel (San Diego)
    • Year and Date
      2011-06-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Synthesis of CXCL14 and Its derivatives utilizing C to N or N to C directive sequential NCL protocol2011

    • Author(s)
      辻耕平
    • Organizer
      22nd American Peptide Symposium
    • Place of Presentation
      Sheraton hotel (San Diego)
    • Year and Date
      2011-06-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] AMP化タンパク質の機能解明に向けたAMP化アミノ酸誘導体の創製2011

    • Author(s)
      小倉圭司
    • Organizer
      日本ケミカルバイオロジー学会第6回年会
    • Place of Presentation
      東京工業大学(東京都)
    • Year and Date
      2011-05-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] プロリン型触媒を用いた刺激応答型アミノ酸の不斉合成2011

    • Author(s)
      重永章
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡市
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] 標的タンパク質の効率的濃縮と同定を指向したトレーサブルリンカーの開発2011

    • Author(s)
      山本純
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡市
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] ヒトiPS細胞に対する神経分化誘導能を持つ新規化合物の探索2011

    • Author(s)
      辻大輔
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡市
    • Year and Date
      2011-03-31
    • Related Report
      2010 Annual Research Report
  • [Presentation] クリプトチオエステル:ネイティブケミカルライゲーションに直接適用可能なペプチドチオエステル等価体2011

    • Author(s)
      佐藤浩平
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡市
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] CXCL14およびその誘導体の多様性指向型化学合成とその活性評価2011

    • Author(s)
      辻耕平
    • Organizer
      日本薬学会第131回年会
    • Place of Presentation
      静岡市
    • Year and Date
      2011-03-29
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of stimulus responsive thiol releasing device for controlling activity of cysteine protease2010

    • Author(s)
      森下巧
    • Organizer
      The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences
    • Place of Presentation
      淡路市
    • Year and Date
      2010-12-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Design and synthesis of recapturable cleavable linker for efficient enrichment and specific labeling of target proteins2010

    • Author(s)
      山本純
    • Organizer
      The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences
    • Place of Presentation
      淡路市
    • Year and Date
      2010-12-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of nonhydrolyzable AMPylated amino acid mimetics for revealing physiological role of AMPylated protein2010

    • Author(s)
      小倉圭司
    • Organizer
      The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences
    • Place of Presentation
      淡路市
    • Year and Date
      2010-12-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Native chemical ligation utilizing N-peptidyl anilide auxiliary2010

    • Author(s)
      佐藤浩平
    • Organizer
      The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences
    • Place of Presentation
      淡路市
    • Year and Date
      2010-12-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Diversity-oriented Synthesis of CXCL14 and Its Derivatives2010

    • Author(s)
      辻耕平
    • Organizer
      The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences
    • Place of Presentation
      淡路市
    • Year and Date
      2010-12-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Identification of novel chemical inducer for differentiation of neuronal precursor cells from human induced pluripotent stem cells2010

    • Author(s)
      辻大輔
    • Organizer
      The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences
    • Place of Presentation
      淡路市
    • Year and Date
      2010-12-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of amide bond cleavage device with application to chemical biology use2010

    • Author(s)
      大高章
    • Organizer
      5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都市
    • Year and Date
      2010-12-09
    • Related Report
      2010 Annual Research Report
  • [Presentation] Enantioselective synthesis of stimulus-responsive amino acid via pyrrolidinyl tetrazole catalyzed asymmetric α-amination of aldehyde2010

    • Author(s)
      重永章
    • Organizer
      5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都市
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Stimulus Responsive Thiol Releasng System for Controlling Activity of Cysteine Protease2010

    • Author(s)
      森下巧
    • Organizer
      5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都市
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of Recapturable Cleavable Linker for Efficient Enrichment and Specific Labeling of Target Proteins2010

    • Author(s)
      山本純
    • Organizer
      5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都市
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of nonhydrolyzable AMPylated amino acid analogues for uncovering the physiological role of AMPylation2010

    • Author(s)
      小倉圭司
    • Organizer
      5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都市
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Native chemical ligation using N-peptidyl anilide as crypto-thioester2010

    • Author(s)
      左藤浩平
    • Organizer
      5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都市
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis and biological evaluation of CXCL14 and its derivatives2010

    • Author(s)
      辻耕平
    • Organizer
      5th International Peptide Symposium in conjunction with 47th Japanese Peptide Symposium
    • Place of Presentation
      京都市
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] 未分化細胞に対する神経分化誘導作用を持つ化合物の探索と構造活性相関2010

    • Author(s)
      辻大輔
    • Organizer
      第83回日本生化学会・第33回日本分子生物学会合同大会
    • Place of Presentation
      神戸市
    • Year and Date
      2010-12-08
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of stimulus-responsive amino acid with peptide bond-cleavage ability and its application for controlling peptidyl function2010

    • Author(s)
      重永章
    • Organizer
      The Second Decennial Meeting Between The University of Tokushima and Seoul National University on Pharmaceutical Sciences
    • Place of Presentation
      淡路市
    • Year and Date
      2010-11-23
    • Related Report
      2010 Annual Research Report
  • [Presentation] 標的タンパク質の効率的濃縮と同定を指向したCleavable Linkerの創製2010

    • Author(s)
      山本純
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都市
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] AMP化タンパク質の機能解明に向けたフォスファターゼ抵抗性AMP化アミノ酸の創製2010

    • Author(s)
      小倉圭司
    • Organizer
      第29回メディシナルケミストリーシンポジウム
    • Place of Presentation
      京都市
    • Year and Date
      2010-11-18
    • Related Report
      2010 Annual Research Report
  • [Presentation] ライブラリ構築を志向したCXCL14およびその誘導体の合成と活性評価2010

    • Author(s)
      辻耕平
    • Organizer
      創薬懇話会2010
    • Place of Presentation
      蔵王町
    • Year and Date
      2010-11-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] システインプロテアーゼの活性調節を指向した機能性分子の開発2010

    • Author(s)
      森下巧
    • Organizer
      第49回日本薬学会病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      米子市
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] 標的タンパク質の効率的濃縮と同定を指向したCleavable Linkerの開発2010

    • Author(s)
      山本純
    • Organizer
      第49回日本薬学会病院薬剤師会中国四国支部学術大会
    • Place of Presentation
      米子市
    • Year and Date
      2010-11-06
    • Related Report
      2010 Annual Research Report
  • [Presentation] Synthesis of fluoroalkene dipeptide isosteres (FADIs) using intramolecular redox reaction with their incorporation into biologically active peptide2010

    • Author(s)
      辻耕平
    • Organizer
      第38回構造活性相関シンポジウム
    • Place of Presentation
      徳島市
    • Year and Date
      2010-10-30
    • Related Report
      2010 Annual Research Report
  • [Presentation] Development of peptide bond cleavage device and its application for chemical biology use2010

    • Author(s)
      大高章
    • Organizer
      The 13rd Akabori Conference
    • Place of Presentation
      Leipzig, Germany
    • Year and Date
      2010-09-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] "化学"でペプチド・タンパク質を操る-神経変性疾患治療を目指して-2010

    • Author(s)
      重永章
    • Organizer
      日本の薬学、四国の薬学部
    • Place of Presentation
      徳島
    • Year and Date
      2010-06-12
    • Related Report
      2011 Final Research Report
  • [Presentation] "化学"でペプチド・タンパク質を操る-神経変性疾患治療を目指して-2010

    • Author(s)
      重永章
    • Organizer
      日本の薬学、四国の薬学部
    • Place of Presentation
      徳島市
    • Year and Date
      2010-06-12
    • Related Report
      2010 Annual Research Report
  • [Presentation] ターゲットタンパク質の効率的濃縮と同定を指向したCleavable Linkerの開発2010

    • Author(s)
      山本純
    • Organizer
      日本ケミカルバイオロジー学会第5回年会
    • Place of Presentation
      横浜市
    • Year and Date
      2010-05-18
    • Related Report
      2010 Annual Research Report
  • [Book] 刺激応答型アミノ酸の開発と生命科学分野への応用2012

    • Author(s)
      重永章、山本純、大高章
    • Publisher
      メディカルドゥ
    • Related Report
      2011 Final Research Report
  • [Book] 遺伝子医学MOOK 21号最新ペプチド合成技術とその創楽研究への応用「刺激応答型アミノ酸の開発と生命科学分野への応用」2012

    • Author(s)
      重永章
    • Publisher
      メディカルドゥ(印刷中)
    • Related Report
      2011 Annual Research Report
  • [Book] 第10章最近のペプチド・タンパク質の化学合成について2010

    • Author(s)
      大高章、重永章
    • Publisher
      建帛社
    • Related Report
      2011 Final Research Report
  • [Book] 機能性タンパク質・ペプチドの生体利用「第10章 最近のペプチド・タンパク質の化学合成について」2010

    • Author(s)
      大高章
    • Total Pages
      27
    • Publisher
      建帛社
    • Related Report
      2010 Annual Research Report
  • [Remarks]

    • URL

      http://www.tokushima-u.ac.jp/ph/faculty/labo/otaka/

    • Related Report
      2011 Final Research Report
  • [Remarks]

    • Related Report
      2011 Annual Research Report

URL: 

Published: 2010-08-23   Modified: 2016-04-21  

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