Synthetic study of natural products with complex structures using a cascade reaction

• Project/Area Number: 22790016
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Chemical pharmacy
• Research Institution: Nagoya City University
• Principal Investigator: KATO Nobuki 名古屋市立大学, 大学院・薬学研究科, 助教 (50400221)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 有機反応学 / 合成化学 / カスケード反応 / 全合成 / 8π電子環状反応

Research Abstract

Construction of tricyclo[3.2.1.0^<2, 7>] octane structure using a cascade reaction including a formation of o-quinodimethane, 6.electrocyclization and intramolecular Diels-Alder reaction was attempted. Although the desired reaction did not proceed, an useful 8-membered ring construction reaction was discovered.

Research Products

• [Journal Article] Photocontrol of Peptide Function : Backbone Cyclization Strategy with Photocleavable Amino Acid (2011)
  • Author(s): Naoki Umezawa, Yuka Noro, Kazuhiro Ukai, Nobuki Kato, Tsunehiko Higuchi
  • Journal Title: ChemBioChem Volume: 12 Pages: 1694-1698
• [Journal Article] FLAG Tagging by CuAAC and Nano-gram Scale Purification of the Target Protein for Bioactive Metabolite Concerning Circadian Rhythmic Leaf Movement of Leguminosae (2010)
  • Author(s): Yoshiyuki Manabe, Makoto Mukai, Satoko Ito, Nobuki Kato, Minoru Ueda
  • Journal Title: Chem. Commun Pages: 469-471
• [Journal Article] Facile synthesis of peptide-porphyrin conjugates : Towards artificial catalase (2010)
  • Author(s): Naoki Umezawa, Nobuyoshi Matsumoto, Shinsuke Iwama, Nobuki Kato, Tsunehiko Higuchi
  • Journal Title: Bioorg. Med. Chem. Volume: 18 Pages: 6340-6350
• [Journal Article] FLAG Tagging by CuAAC and Nano-gram Scale Purification of the Target Protein for Bioactive Metabolite Concerning Circadian Rhythmic Leaf Movement of Leguminosae (2010)
  • Author(s): Yoshiyuki Manabe
  • Journal Title: Chemical Communications Pages: 469-471
  • Peer Reviewed
• [Journal Article] Facile synthesis of peptide-porphyrin conjugates : Towards artificial catalase (2010)
  • Author(s): Naoki Umezawa
  • Journal Title: Bioorganic Medicinal Chemistry Volume: 18 Pages: 6340-6350
  • Peer Reviewed
• [Presentation] ルテニウムポルフィリン-ピリジンN-オキシド系による環状エーテル類の効率的酸化反応 (2011)
  • Author(s): 浜口雄、加藤信樹、梅澤直樹、樋口恒彦
  • Organizer: 日本薬学会第131年会
  • Place of Presentation: 静岡
  • Year and Date: 2011-03-29
• [Presentation] Salvileucalin Bの合成研究 (2010)
  • Author(s): 田口知世, 加藤信樹, 梅澤直樹, 樋口恒彦
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2010
  • Place of Presentation: 静岡
  • Year and Date: 2010-11-28
• [Presentation] ルテニウムポルフィリンの触媒するエーテル類の効率的酸化 (2010)
  • Author(s): 浜口雄、加藤信樹、梅澤直樹、樋口恒彦
  • Organizer: 日本病院薬剤師会東海ブロック・日本薬学会東海支部合同学術大会2010
  • Place of Presentation: 静岡
  • Year and Date: 2010-11-28
• [Presentation] 酵素の触媒機構を考慮した効率的活性酸素消去化合物の開発 (2010)
  • Author(s): 則武幸延, 加藤信樹, 梅澤直樹, 樋口恒彦
  • Organizer: 第29回メディシナルケミストリーシンポジウム
  • Place of Presentation: 京都
  • Year and Date: 2010-11-18
• [Presentation] ルテニウムポルフィリンーピリジンN-オキシド系によるエーテル類の効率的酸化反応 (2010)
  • Author(s): 浜口雄、加藤信樹、梅澤直樹、樋口恒彦
  • Organizer: 第43回酸化反応討論会
  • Place of Presentation: 東京
  • Year and Date: 2010-11-13
• [Remarks]
  • URL: http://www.phar.nagoya-cu.ac.jp/hp/ysk/main/main.html
• [Remarks]
  • URL: http://www.phar.nagoya-cu.ac.jp/hp/ysk/index.html
• [Patent(Industrial Property Rights)] Preparation of aminoquinoline compounds as antimalarial agents (2012)
  • Inventor(s): Higuchi, Tsunehiko ; Umezawa, Naoki ; Kato, Nobuki
  • Industrial Property Rights Holder: 公立大学法人名古屋市立大学
  • Acquisition Date: 2012-03-15
  • Overseas
• [Patent(Industrial Property Rights)] COMPOUND HAVING ANTIMALARIAL ACTIVITY AND ANTIMALARIAL DRUG (2011)
  • Inventor(s): Tsunehiko Higuchi, Naoki Umezawa, Nobuki Kato
  • Industrial Property Rights Holder: PUBLIC UNIVERSITY CORP NAGOYA CITY UNIVERSITY
  • Filing Date: 2011-08-29
  • Acquisition Date: 2012-03-15
  • Overseas
• [Patent(Industrial Property Rights)] 抗マラリア活性化合物及び抗マラリア薬 (2010)
  • Inventor(s): 樋口恒彦,梅澤直樹,加藤信樹
  • Industrial Property Rights Holder: 公立大学法人名古屋市立大学
  • Industrial Property Number: 2010-198651
  • Filing Date: 2010-09-06