| Project/Area Number |
22790021
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Tokyo University of Pharmacy and Life Science |
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Principal Investigator |
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| Project Period (FY) |
2010 – 2012
|
| Project Status |
Completed (Fiscal Year 2012)
|
| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 生理活性物質 / 海洋産テルペノイド / 全合成 / 合成化学 / 有機化学 / 海洋天然物 / ジテルペノイド / キツンゴライドB |
|---|
| Research Abstract |
Synthetic study of marine diterpenoid, kitungolide B, contained novel hexahydrocoumalin skeleton was occurred. Reformatsky reaction with zinc, ethyl bromoacetate and aldehyde compound, whichobtained the 3-methyl-2-buten-1-ol via three steps, was carried out. As the results, the nucleophilic attack to the aldehyde moiety, cyclization and elimination reactions were proceeded simultaneously, the desired unsaturated lactone was obtained. The 1,4-addition to the unsaturated lactone followed by ring closing metathesis was provided trans-fused bicyclic lactone compound. Further study of the construction of hexahydrocoumalin skeleton is now on going.
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