| Project/Area Number |
22790026
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Single-year Grants |
|---|
| Research Field |
Chemical pharmacy
|
|---|
| Research Institution | Kinki University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2010 – 2011
|
| Project Status |
Completed (Fiscal Year 2011)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2010: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
|
|---|
| Keywords | 生薬 / 天然物化学 / TNF-α感受性低減作用 / 肝保護作用 / 乳香 / Kaempferia parviflora / Shorea roxburghii / Mammea siamensis / オリゴスチルベノイド / 植物ポリフェノール / Piper chaba / Sapindus rarak / Cistanche tubulosa / piperine / アシル化ジテルペン配糖体 / アシル化フェニルエタノイド配糖体 |
|---|
| Research Abstract |
In order to investigate hepatoprotective constituents by reductive effect of sensitivity to TNF-αfrom medicinal plants, we examined inhibitory effect on TNF-α-induced cytotoxicity in L929 cells as a first screening trial. As the results, several materials such as Thai medicinal plants, Piper chaba(fruit), Sapindus rarak(pericarps), Kaempferia parviflora(rhizomes), Shorea roxburghii(bark), and Mammea siamensis(flowers) and Cistanche tubulosa(stems) were found to inhibit the activity. From those candidate materials, several constituents were investigated as the active compounds. Furthermore, the structural requirements and the mode of action of the active compounds were also examined.
|
