Optimization of chemotherapy for breast cancer by in vivo single molecular imaging of drug delivery system and control of neovasculature permeability
Project/Area Number |
22790031
|
Research Category |
Grant-in-Aid for Young Scientists (B)
|
Allocation Type | Single-year Grants |
Research Field |
Physical pharmacy
|
Research Institution | Tohoku University |
Principal Investigator |
KAWAI Masaaki 東北大学, 大学院・医学系研究科, 助教 (80513530)
|
Project Period (FY) |
2010 – 2011
|
Project Status |
Completed (Fiscal Year 2011)
|
Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 虚血性腫瘍 / Quantum Dot / in vivoイメージング / 血管内皮細胞増殖因子 / マウス片側肢虚血モデル |
Research Abstract |
To image the neovasculature in the ischemic portion, VEGF-aQDs complexes and mouse ischemic limb model were structured. Injected VEGF-aQDs were attached to the wall of the neovasculature about 3. 3 times higher compared to the aQDs (control). Injected VEGF-aQDs were also attached to the wall of the neovasculature about 2. 4 times higher compared to the wall of the normal vessel. We analyzed the distribution of VEGF receptor on the wall of the neovasculature.
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Report
(3 results)
Research Products
(10 results)