Optimization of chemotherapy for breast cancer by in vivo single molecular imaging of drug delivery system and control of neovasculature permeability

• Project/Area Number: 22790031
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Physical pharmacy
• Research Institution: Tohoku University
• Principal Investigator: KAWAI Masaaki 東北大学, 大学院・医学系研究科, 助教 (80513530)
• Project Period (FY): 2010 – 2011
• Project Status: Completed (Fiscal Year 2011)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 虚血性腫瘍 / Quantum Dot / in vivoイメージング / 血管内皮細胞増殖因子 / マウス片側肢虚血モデル

Research Abstract

To image the neovasculature in the ischemic portion, VEGF-aQDs complexes and mouse ischemic limb model were structured. Injected VEGF-aQDs were attached to the wall of the neovasculature about 3. 3 times higher compared to the aQDs (control). Injected VEGF-aQDs were also attached to the wall of the neovasculature about 2. 4 times higher compared to the wall of the normal vessel. We analyzed the distribution of VEGF receptor on the wall of the neovasculature.

Research Products

• [Journal Article] Body mass index and survival after breast cancer diagnosis in Japanese women (2012)
  • Author(s): Kawai M, Minami Y, Nishino Y, Fukamachi K, Ohuchi N, Kakugawa Y
  • Journal Title: BMC Cancer Volume: 12 Pages: 149-149
  • Peer Reviewed
• [Journal Article] Harms of screening mammography for breast cancer in Japanese women (2012)
  • Author(s): Kasahara Y, Kawai M, Tsuji I, Tohno E, Yokoe T, Irahara M, Tangoku A, Ohuchi N
  • Journal Title: Breast Cancer Volume: (in press)
  • Peer Reviewed
• [Journal Article] Being breastfed in infancy and adult breast cancer risk among Japanese women (2012)
  • Author(s): Minami Y, Nishino Y, Kawai M, Kakugawa Y
  • Journal Title: Cancer Causes Control Volume: 23 Pages: 389-398
  • Peer Reviewed
• [Journal Article] Alcohol consumption and breast cancer risk in Japanese women : The Miyagi Cohort Study (2011)
  • Author(s): Kawai M, Minami Y, Kakizaki M, Kakugawa Y, Nishino Y, Fukao A, Tsuji I, Ohuchi N
  • Journal Title: Breast Cancer Res Treat Volume: 128 Pages: 817-825
  • Peer Reviewed
• [Journal Article] Alcohol consumption and breast cancer risk in Japanese women : The Miyagi Cohort Study (2011)
  • Author(s): Kawai M, Minami Y, Kakizaki M, Kakugawa Y, Nishino Y, Fukao A, Tsuji I, Ohuchi N.
  • Journal Title: Breast Cancer Res Treat Volume: (未定 in press)
  • Peer Reviewed
• [Presentation] Molecular Imaging of DDS with Nano-Technology (2010)
  • Author(s): Kawai M, Gonda K, Takeda M, Ohuchi N
  • Organizer: 2010 Taipei International Breast Cancer Symposium (2010TIBCS)
  • Place of Presentation: Taipei, ROC
• [Book] 臨床検査「更年期における乳腺の画像検査」 (2011)
  • Author(s): 多田寛、石田孝宣、甘利正和、河合賢朗、大内憲明
  • Publisher: 医学書院
• [Book] 乳がん診療最前線, 治療「乳がん検診」 (2011)
  • Author(s): 多田寛、河合賢朗、大内憲明
  • Publisher: 南山堂
• [Book] 乳がん診療最前線治療、治療「乳がん検診」 (2011)
  • Author(s): 多田寛、河合賢朗、大内憲明
  • Publisher: 南山堂
• [Book] 更年期における乳腺の画像検査 (2011)
  • Author(s): 多田寛, 石田孝宣, 甘利正和, 河合賢朗, 大内憲明
  • Publisher: 医学書院(未定)