Development of target-specific gene therapy system by using cell surface adhesive interferon.
| Project/Area Number |
22790034
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
TAKAHASHI Yuki 京都大学, 大学院・薬学研究科, 助教 (00547870)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2010: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | ドラッグデリバリー / 遺伝子治療 / インターフェロン / 薬学 |
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| Research Abstract |
In the present study, we developed IFN-γderivative that can adhere on cellular surface in order to selectively increase IFN-γconcentration at gene delivery site. Developed IFN-γwas demonstrated to be able to adhere on the cell surface and selective biological activity obtained by gene delivery of the developed IFN-γderivative was specific in the gene-delivered organ. We found that the developed system was effective in reducing adverse side effect without reducing antitumor effect at target tissue compared to the normal IFN-γgene therapy system.
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Report
(3 results)
Research Products
(9 results)
