Synthesis and evaluation of an in vivo imaging probe for tumor based on the intracellular transporting system
| Project/Area Number |
22790035
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | National Cardiovascular Center Research Institute |
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Principal Investigator |
KAWASHIMA Hidekazu 独立行政法人国立循環器病研究センター, 画像診断医学部, 室長 (70359438)
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| Project Period (FY) |
2010 – 2011
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| Project Status |
Completed (Fiscal Year 2011)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2011: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2010: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | 腫瘍 / 分子イメージング / ペプチドトランスポーター / 陽電子断層撮像法 / RI-DDS |
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| Research Abstract |
Peptide transporter-1(PEPT1) is expected to be a target for the tumor-selective molecular delivery. Because several phenylalanine-containing dipeptides are well recognized by PEPT1 as substrates, we designed and synthesized a peptidergic compound consisting of 2-[^<18> F] fluoronicotinic acid and phenylalanine(2-[^<18> F] FNA-Phe) as a PET probe for tumor imaging. The uptake to human pancreatic tumor cells(AsPC-1) that expresses PEPT1 was measured in vitro, which demonstrated that 2-[^<18> F] FNA-Phe was taken up into cells via PEPT1. When 2-[^<18> F] FNA-Phe was intravenously injected to BALB/c nude mice bearing AsPC-1, the tumor was clearly visualized.
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Report
(3 results)
Research Products
(2 results)
