| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Research Abstract |
In the present study, to make an attempt to confer a tumor cell-selectivity to M- -CyD, we newlysynthesized folate-appended M- -CyD (FA-M- -CyD), and evaluated the potentials as its noveltumor-selective carrier for antitumor drugs. Doxorubicin/FA-M- -CyD complex showed the potentantitumor activity after single intravenous injection to tumor-bearing mice, compared to doxorubicinalone and DOX/M- -CyD complex. In conclusion, the present study demonstrated the potentials ofFA-M- -CyD as a novel tumor-selective carrier for antitumor drugs.
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