| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Research Abstract |
A spray-dried powder (SDP) of trans-glycosylated materials and and poorly water soluble drugs were prepared by a spray-drying method. The SDPs resulted in pronounced improvementin both the dissolution rate and solubility of drugs. Hsp-G molecules self-associated into particular small micelles. Solubility enhancement was due to the incorporation of drugs into Hsp-G micelle. Fluorescence study revealed that the hydrophobic steviol-skeleton of Stevia-G made a hydrophobic core around a hydrophobic molecule, and the micellar aggregation number of Stevia-G was estimated as ca.15. This specific structure formed by Stevia-G molecules led to an enhancement of the apparent solubility of poorly water-soluble drugs. Rutin-G also showed pronounced improvement in both thedissolution rate and solubility of APIs, indicating the possibility of the new type nano-composite formation.
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