Nano-composite formation for various pharmaceutical formulations.
| Project/Area Number |
22790041
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Osaka University of Pharmaceutical Sciences (2012)
Gifu Pharmaceutical University (2010-2011) |
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Principal Investigator |
TOZUKA Yuichi 大阪薬科大学, 薬学部, 教授 (50312963)
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| Project Period (FY) |
2010 – 2012
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| Project Status |
Completed (Fiscal Year 2012)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2012: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2011: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2010: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 製剤学 / ナノコンポジット / 機能性添加剤 / 糖転移ルチン / 溶解性改善 / 吸収性改善 / 糖転移化合物 / ナノ集合体 / 難水溶性薬物 / 分子間相互作用 / 機能性粒子 |
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| Research Abstract |
A spray-dried powder (SDP) of trans-glycosylated materials and and poorly water soluble drugs were prepared by a spray-drying method. The SDPs resulted in pronounced improvementin both the dissolution rate and solubility of drugs. Hsp-G molecules self-associated into particular small micelles. Solubility enhancement was due to the incorporation of drugs into Hsp-G micelle. Fluorescence study revealed that the hydrophobic steviol-skeleton of Stevia-G made a hydrophobic core around a hydrophobic molecule, and the micellar aggregation number of Stevia-G was estimated as ca.15. This specific structure formed by Stevia-G molecules led to an enhancement of the apparent solubility of poorly water-soluble drugs. Rutin-G also showed pronounced improvement in both thedissolution rate and solubility of APIs, indicating the possibility of the new type nano-composite formation.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Transglycosylated Rutin-Specific Non-Surface-Active Nanostructure Affects Absorption Enhancement of Flurbiprofen, Euro2012
Author(s)
Y. Tozuka, K. Higashi, T. Morita, M.Nishikawa, H. Uchiyama, J. Zhang, K. Moribe, K. Nishikawa, H. Takeuchi, K. Yamamoto
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Journal Title
J. Pharm. Biopharm
Volume: 82
Pages: 120-126
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